精神分裂症患者神经营养因子血清浓度与临床症状相关性研究

万静++++++黄彩英++++++薛坤喜++++++胡静++++++平军娇++++++杜宝国

[摘要]目的 研究首发精神分裂症患者脑源性神经营养因子（BDNF）及神经生长因子（NGF）的血清浓度与临床症状的相关性。方法 以2015年9月～2016年11月我院早期干预科住院的38例首发精神分裂症患者和50例健康体检者为研究对象，使用酶联免疫吸附法（ELISA）测定BDNF和NGF血清浓度，使用阳性和阴性症状量表（PANSS）评定患者组临床症状，对两组BDNF、NGF血清濃度进行比较，使用Pearson相关分析对患者组PANSS分和BDNF、NGF血清浓度进行相关分析。结果 患者组的血清BDNF水平[（2913.19±638.30）pg/ml]显著低于对照组[（3553.05±685.98）pg/ml]（t=4.465，P<0.01）。患者组的血清NGF水平[（36.96±8.28）pg/ml]显著低于对照组[（44.30±10.94）pg/ml]（t=3.450，P<0.01）。患者组BDNF血清浓度与PANSS各项分之间没有相关性；患者组NGF血清浓度与PANSS阴性分成负相关（r=-0.256，P<0.05），与PANSS总分、阳性分和一般分之间没有相关性；患者组BDNF与NGF血清浓度成正相关（r=0.378，P<0.01）。结论 精神分裂症患者存在认知功能损害，精神分裂症患者血清NGF可能影响神经生长发育；BDNF和NGF在精神分裂症发病机制中所起的作用相似。

[关键词]精神分裂症；脑源性神经营养因子；神经生长因子

[中图分类号] R749.05 [文献标识码] A [文章编号] 1674-4721（2017）07（a）-0050-03

Research on serum correlation of neurotrophin and clinical symptoms in first episode Schizophrenia

WAN Jing HUANG Cai-ying XUE Kun-xi HU Jing PING Jun-jiao DU Bao-guo

Department of Early Intervention，the Third People′s Hospital of Zhongshan，Guangdong Prouince，Zhongshan 528451，China

[Abstract]Objective To study the correlation among brain-derived neurotrophic factor（BDNF），nerve gowth factor（NGF）and the clinical manifestation in first episode schizophrenia.Methods Double antibody sandwich enzyme-linked immunosorbent assay （ELISA） was adopted to quantitate BDNF and NGF serum levels of 38 first episode schizophrenic patients hospitalized in Department of Early Intervention of our Hospital from September 2015 to November 2016 and 50 healthy people for medical examinations.Positive and negative syndrome scale（PANSS） was used to evaluate the clinical state of the patients.BNDF and NGF serum concentration of the two groups was analyzed.Pearson correlative analysis was adopted to analyze the correlation between BDNF，NGF serum concentrations and PANSS scores in patient group.Results No statistical differences was found in age，gender or years of education in two groups.Lower BDNF serum levels[（2913.19±638.30）pg/ml] were found（t=4.465，P<0.01）in the patient group than in healthy subjects[（355.3±685.98）pg/ml].Lower NGF serum concentrations[（36.96±8.28）pg/ml] were found （t=3.450，P<0.01）in the patient group than in the controls [（44.30±10.94）pg/ml].BDNF serum concentrations and PANSS scores were not correlated in patient group.There were no correlations found among，PANSS-positive scores，PANSS-general scores and PANSS-Total scores in the patient group，however，NGF serum levels were negatively related to PANSS-negtive scores in patient group （r=-0.256，P<0.05）.BDNF was found positively related to NGF serum levels（r=0.378，P<0.01）.Conclusion Cognitive impairments occurred in schizophrenic patients，and NGF in the serum may impact growth and development of nervous system.BDNF and NGF may play similar role on nosogenesis of schizophrenia.

[Key words]Schizophrenia；BDNF；NGF

精神分裂症的病因及发病机理尚未明确。目前对该病最有影响的假说是神经发育假说，尤其是大脑进行性发育障碍的假说[1]。神经营养因子家族的重要成员脑源性神经营养因子（BDNF）和神经生长因子（NGF），均在调节突触可塑性方面具有一定作用，也被广泛认为在调节认知功能发挥重要作用。BDNF和NGF也对多巴胺能神经元和五羟色胺神经元的存活、生长和维持方面具有调控作用，故其可能在精神分裂症病理过程中发挥一定的作用[2]。既往有研究显示精神分裂症BDNF和NGF的血清水平低于正常人群[3]，本研究以首发精神分裂症患者为研究对象，比较了首发精神分裂症患者和对照组的BDNF、NGF血清浓度，进一步分析了患者组BDNF、NGF血清浓度和PANSS各项分三者之间的相关性。

1资料与方法

1.1一般资料

以2015年9月～2016年11月在我院早期干预科住院的38例首发精神分裂症住院患者为研究组。……