英夫利西单抗联合甲氨蝶呤治疗活动性类风湿关节炎的效果及安全性研究

夏志高++++++柳彩阳

[摘要]目的 探讨英夫利西单抗联合甲氨蝶呤对活动性类风湿关节炎（RA）的临床效果以及安全性。方法 选择某院2015年9月～2016年9月收治的70例活动性RA患者，随机分为研究组和对照组，每组35例。给予对照组患者甲氨蝶呤治疗，给予研究组英夫利西单抗治疗+甲氨蝶呤治疗。观察两组的临床效果、临床症状改善情况、相关临床指标变化以及不良反应。结果 治疗后，研究组的临床效果、症状改善情况及相关指标水平变化均显著优于对照组，差异有统计学意义（P<0.05）。结论 二药联合使用，具有临床效果优秀、作用快、症状控制速度迅速、抗炎作用强等特点，安全高效，可在临床大力推广。

[关键词]类风湿关节炎；英夫利西单抗；甲氨蝶呤；安全性

[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-4721（2017）07（a）-0151-03

Efficacy and safety study of Infliximab combined with Methotrexate in the treatment of active rheumatoid arthritis

XIA Zhi-gao1 LIU Cai-yang2

1.Department of Pharmacy，the First People′s Hospital of Guangzhou City in Guangdong Province，Guangzhou 510180，China；2.Department of Endocrine，the First People′s Hospital of Guangzhou City in Guangdong Province，Guangzhou 510180，China

[Abstract]Objective To investigate the clinical therapeutic effect and safety of Infliximab combined with Methotrexate treating active rheumatoid arthritis （RA）.Methods 70 patients with active RA admitted into some hospital from September 2015 to September 2016 were selected and they were randomly divided into study group and control group，and there were 35 cases in each group.The patients of control group were given Methotrexate for treatment，and patients of research group were given Infliximab combined with Methotrexate.The clinical effect，the improvement of clinical symptoms，the change of the related clinical indexes and adverse reaction were compared in two groups.Results After treatment，the changes of clinical treatment effect，symptom improvement and related indicator level were significantly better than those of the control group and the differences were statistically significant （P<0.05）.Conclusion The combination of the two medicines has the characteristics of good clinical effect，fast action，speedy symptom control rate and strong anti-inflammatory action and so on.It is safe and efficient so that it can be greatly promoted in clinic.

[Key words]Rheumatoid arthritis；Infliximab；Methotrexate；Safety

类风湿关节炎（rheumatoid arthritis，RA）的特點为慢性、进行性、对称性和全身性，其本质为自身免疫疾病[1]，现今其致病因尚未明确。类风湿关节炎若诊断或者治疗不及时，将会严重导致关节僵直、畸形、致残等等后果，严重影响患者身体健康以及生活质量[2-3]。有研究指出，英夫利西单抗联合甲氨蝶呤可有效抑制或者阻断炎性细胞的生成，对活动性RA治疗效果较明显[4-5]。本研究选择某院收治的70例活动性RA患者作为研究对象，对活动性RA的临床治疗用药方案进行探讨，为临床用药提供参考，现报道如下。

1资料与方法

1.1一般资料

选择某院2015年9月～2016年9月收治的活动性RA患者70例，随机分为研究组和对照组，每组35例。研究组中，男16例，女19例；年龄43～72岁，平均（48.37±6.78）岁；病程1～11年，平均（5.62±3.10）年。对照组中，男15例，女20例；年龄41～73岁，平均（47.96±6.57）年；病程2～12年，平均（5.87±3.54）年。两组患者在性别、年龄、病程等方面差异无统计学意义（P>0.05），具有可比性。……