Jisuikang, a Chinese herbal formula, increases neurotrophic factor expression and promotes the recovery of neurological function after spinal cord injury
2017-10-11 02:21YangGuoYongMaYalanPanSuyangZhengJianweiWangGuichengHuang
中国神经再生研究（英文版） 2017年9期
Yang Guo, Yong Ma, Ya-lan Pan Su-yang Zheng Jian-wei Wang, Gui-cheng Huang
1 Institute of Traumatology & Orthopedics and Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology,Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
2 Department of Traumatology & Orthopedics, Af filiated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
3 Department of Traumatology & Orthopedics, Wuxi Hospital of Traditional Chinese Medicine Af filiated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu Province, China
RESEARCH ARTICLE
Jisuikang, a Chinese herbal formula, increases neurotrophic factor expression and promotes the recovery of neurological function after spinal cord injury
Yang Guo1,#, Yong Ma1,2,#, Ya-lan Pan1, Su-yang Zheng1, Jian-wei Wang3, Gui-cheng Huang1,＊
1 Institute of Traumatology & Orthopedics and Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology,Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
2 Department of Traumatology & Orthopedics, Af filiated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
3 Department of Traumatology & Orthopedics, Wuxi Hospital of Traditional Chinese Medicine Af filiated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu Province, China
Graphical Abstract
Jisuikang, a Chinese herb formula, can upregulate the expression of brain-derived neurotrophic factor(BDNF) and nerve growth factor (NGF) for a long time after spinal cord injury
Abstract
Te Chinese medicine compound,Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spinal cord injury. However, the mechanism remains unclear. Tus, we established a rat model of acute spinal cord injury using a modified version of Allen’s method.Jisuikang(50, 25, and 12.5 g/kg/d) and prednisolone were administered 30 minutes after anesthesia. Basso, Beattie, and Bresnahan locomotor scale scores and the oblique board test showed improved motor function recovery in the prednisone group and moderate-doseJisuikanggroup compared with the other groups at 3–7 days post-injury. Te rats in the moderate-doseJisuikanggroup recovered best at 14 days post-injury. Hematoxylin-eosin staining and transmission electron microscopy showed that the survival rate of neurons in treatment groups increased after 3–7 days
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