吴元华 葛明亮 吴盛赞
[摘要] 目的 分析不同CT成像方法在脑胶质瘤边界确定中的差异性。 方法 分析2012年6月~2016年12月于我院就诊的43例脑胶质瘤患者的CT灌注与普通增强CT的数据资料,根据所获得的图像分别勾勒并测量脑胶质瘤面积,比较两种成像方法所获得的病灶截面面积。 结果 术前胶质瘤患者CT灌注成像中胶质瘤勾勒的面积为(11.63±2.25)cm2,明显大于常规增强CT中胶质瘤勾勒的面积(10.06±2.13)cm2,差异具有统计学意义(P<0.05);术后残留或复发患者中CT灌注成像中胶质瘤勾勒的面积为(11.14±2.12)cm2,明显大于常规增强CT中胶质瘤勾勒的面积(9.78±2.03)cm2,差异具有统计学意义(P<0.05)。 结论 CT灌注成像所确定的肿瘤范围更能反映出胶质瘤的浸润范围,有助于指导胶质瘤的治疗,值得在临床上推广。
[关键词] 脑内胶质瘤;CT灌注成像;增强CT;肿瘤边界
[中图分类号] R739.4 [文献标识码] B [文章编号] 1673-9701(2017)24-0094-03
[Abstract] Objective To analyze the difference of different CT imaging methods in the determination of brain glioma boundary. Methods The data of CT perfusion and generally enhanced CT in 43 patients with brain glioma who were admitted to our hospital from June 2012 to December 2016 were analyzed. According to the obtained images, the brain glioma area was outlined and measured. The obtained lesion cross-sectional area was compared between the two imaging methods. Results The outlined area of glioma in CT perfusion imaging was (11.63±2.25) cm2 in preoperative glioma patients, significantly higher than that of (10.06±2.13) cm2 in conventional enhanced CT, the difference was statistically significant (P<0.05); the outlined area of glioma in CT perfusion imaging was (11.14±2.12) cm2 in postoperative residual or relapsed patients, significantly higher than that of (9.78±2.03) cm2 in the conventional enhanced CT, the difference was statistically significant(P<0.05). Conclusion The range of tumor determined by CT perfusion imaging can reflect the infiltration range of glioma, and it can help to guide the treatment of glioma, which is worthy to be popularized in clinical practice.
[Key words] Brain glioma; CT perfusion imaging; Enhanced CT; Tumor boundary
膠质瘤,又称为胶质细胞瘤,起源于神经间质细胞,发生于神经外胚层的肿瘤,是颅内最多发的肿瘤,占所有颅内肿瘤的33.3%~58.6%[1]。目前,胶质瘤主要采取手术治疗,但是由于该肿瘤多为浸润性生长,与脑组织无明显的确定界限,所以较难彻底切除[2]。增强CT结果只能显示胶质瘤患者的血脑屏障破坏情况,并不能准确显示胶质瘤细胞的浸润范围,从而不能确定胶质瘤的真正边界,会致使所测肿瘤范围过小[3-4]。随着科技的发展,多层螺旋CT技术已经广泛应用于医学影像领域,其中,CT灌注技术越来越受到广大医学工作者的青睐和认可[5]。CT灌注成像技术扫描后可显示较清晰的彩图以及定量灌注数值,准确确定胶质瘤边界。本研究选取2012年6月~2016年12月于我院就诊的43例脑胶质瘤患者为研究对象,进行CT灌注成像扫描与普通增强CT成像扫描,比较不同成像方法对脑内胶质瘤的边界确定效果。
1 资料与方法……p>