氨磺必利与阿立哌唑治疗以阴性症状为主的精神分裂症的对照研究

魏利群

[摘要]目的 探討氨磺必利与阿立哌唑治疗以阴性症状为主精神分裂症的临床效果与安全性。方法 选取2017年5～12月我院收治的80例以阴性症状为主的精神分裂症患者作为研究对象，将其随机分为对照组和研究组，每组各40例。研究组患者口服氨磺必利片治疗，对照组患者口服阿立哌唑治疗，两组患者均治疗8周。比较两组患者治疗前和治疗2、4、8周后的治疗效果、阳性和阴性综合征量表（PANSS）评分及不良反应发生情况。结果 治疗8周后，研究组患者的治疗总有效率为76.92%，对照组患者的治疗总有效率为75.67%，两组患者的治疗总有效率比较，差异无统计学意义（P>0.05）。治疗2周后，研究组患者的阴性因子评分明显低于治疗前及对照组，差异均有统计学意义（P<0.05），但对照组的阴性因子评分与治疗前比较，差异无统计学意义（P>0.05）。治疗4周后，两组患者的阴性因子评分均明显低于治疗前，差异有统计学意义（P<0.05）。研究组患者不良反应发生率（41.02%）低于对照组（54.05%），差异有统计学意义（P<0.05）。结论 氨磺必利治疗以阴性症状为主的精神分裂症的临床效果与采用阿立哌唑治疗相当，但氨磺必利起效快，不良反应少，更加安全，依从性好，值得推广应用。

[关键词]氨磺必利；阿立哌唑；阴性症状；精神分裂症

[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2018）4（b）-0117-03

A controlled clinical study of Amisulpride and Aripiprazole in treatment of patients with negative symptoms of schizophrenia

WEI Li-qun

Department of Psychiatry，the Fourth People′s Hospital of Jingdezhen，Jiangxi Province，Jingdezhen 333000，China

[Abstract]Objective To compare the efficacy and safety between Amisulpride and Aripiprazole in the treatment of patients with negative symptoms of schizophrenia.Methods A total of 80 Patients with negative symptoms of schizophrenia from May to December in 2017 treated in our hospital were selected as the research objects，all the patients were randomly divided into the control group and the study group，40 cases in each group.In the study group，the patients were treated with oral Amisulpride Tablets，and patients in the control group were treated with oral Aripiprazole.Both groups were treated for 8 weeks.The therapeutic effect，the positive and negative syndrome scale （PANSS） scores and adverse reactions were compared between two groups of patients before and after treatment 2，4 and 8 weeks.Results After 8 weeks of treatment，the total efficiency of the study group was 76.92%，and the the total efficiency of the control group was 75.67%，there was no significant difference between the two groups （P>0.05）.After 2 weeks of treatment，the negative factor score of the study group was significantly lower than before treatment and the control group，the differences were statistically significant （P<0.05），while after 2 weeks of treatment，the negative factor score in the control group was not statistically significant compared with that before treatment （P>0.05）.After 4 weeks of treatment，the scores of negative factors in both groups were significantly lower than before treatment，and the differences were statistically significant （P<0.05）.The incidence of adverse reactions in the study group （41.02%） was lower than that in the control group （54.05%），and the difference was statistically significant （P<0.05）.Conclusion The effect of Amisulprideis equivalent to Aripiprazolein treatment of patients with negative symptoms of schizophrenia，but Amisulpride has faster onset time，less adverse reactions，more safety and better compliance.It is worth popularizing the application.

[Key words]Amisulpride；Aripiprazole；Negative symptoms；Schizophrenia

精神分裂症为病因不明的一组症状和体征的集合，多发于青春后期或成年早期，表现为思维、幻觉、情感和行为等多方面的障碍，病程多迁延，给患者及其家庭带来了严重的后果。临床上，精神分裂症患者多以阴性症状（情感平淡和迟钝、思维贫乏、意志缺乏、兴趣或社交缺乏及注意障碍）为主，易被患者或其家属忽略，但往往阴性症状为主的首发精神分裂症的治疗效果及预后差，治疗难度也较高[1]，是精神分裂症患者致残的主要原因之一[2]。如何优化精神分裂症阴性症状治疗的效果及安全性，是精神医学学科关注的一个重要问题[3-4]。目……