朱国兴 和凤领
【摘要】目的: 分析SLE患者的临床表现及诊治情况。方法:对30例系统性红斑狼疮病例的临床表现及实验室资料进行分析。结果: 蝶形红斑为最常见的皮疹,系统损害以消化系统及呼吸系统为常见。实验室指标中以ANA、抗dsDNA阳性、血沉增快、补体下降多见。结论:早期诊断,皮质类固醇激素的规则治疗是决定预后的重要因素之一,对于危重患者可应用皮质类固醇或联合环磷酰胺冲击治疗。
【关键词】红斑狼疮;系统性;实验室;治疗
【中图分类号】R758.61
【文献标志码】A
【文章编号】1005-0019(2018)07-024-01
Clinical treatment and observation of systemic lupus erythematosus
Zhu Guo XingHe Feng Ling
Caoxian county hospital in Heze, Shandong Heze, Shandong 274000
Abstract Objective:Purpose; The clinical manifestations and diagnosis and treatment of SLE patients were analyzed.Methods: The clinical and laboratory data of 30 patients with systemic lupus erythematosus were analyzed.Results: Butterfly erythema is the most common rash. Systemic damage is common in the digestive system and respiratory system. Laboratory indicators included ANA, dsDNA positive, erythrocyte sedimentation rate, and decreased complement. Conclusion: Early diagnosis, the regular treatment of corticosteroids is one of the important factors to determine the prognosis. For critically ill patients, corticosteroid or combined cyclophosphamide can be used for impact therapy.
Key words: Lupus erythematosus (lupus erythematosus); Systematicness;Laboratory;Treatment
系統性红斑狼疮((简称SLE)),是一种全身性自身免疫性疾病,是一种累及多系统、多器官的具有多种自身抗体的自身免疫性疾病。SLE几乎均有肾脏累及,肾脏受累及进行性肾功能损害是本病主要死亡原因之一[1]。因此,SLE的早期诊断和有效治疗有助于改善预后。现将我院2013年3月~2017年12月住院的SLE患者30例临床资料作回顾性分析,报告如下
1资料与方法
11一般资料30例SLE中男性4例,女性26例,年龄23--49岁,其中以26~41岁的女性发病为最多。病程23个月—3年。
12临床表现初发症状:面部蝶形红斑16例,发热11例;掌跖、甲周及指趾尖紫红色瘀斑10例;口腔溃疡9例 ;关节痛8例;四肢浮肿5例;面部盘状红斑2例;腰痛1例;另有胸闷、咳嗽、停经、鼻衄及皮下出血为首发症状各12例。临床表现为乏力23例;发热12例;肾脏损害17例,其中肾炎13例,狼疮性肾病综合症4例;关节炎14例;面部蝶形红斑12例,其它暴露部位皮疹17例; 18例出现消化系统症状,其中食欲减退14例;口腔粘膜水疱、糜烂或溃疡11例;……