肝动脉栓塞化疗术治疗原发性肝癌的临床研究

陈作波 刘秋芳 洪可仲

[摘要]目的 探討肝动脉化疗栓塞术（TACE）治疗原发性肝癌的临床效果。方法 选择2010年1月～2014年5月我院收治的100例原发性肝癌患者作为研究对象，随机将其分成观察组和对照组，每组各50例。观察组采取TACE进行治疗，对照组采取支持治疗法进行治疗。治疗结束后，观察记录两组临床治疗效果、无进展生存期（PFS）、总生存期（OS）以及不良反应发生情况，并比较分析。结果 两组客观缓解率与疾病控制率比较，差异无统计学意义（P>0.05）；观察组PFS、OS均值分别为（11.25±0.84）、（18.57±0.99）个月，对照组则依次为（7.51±0.67）、（17.03±0.89）个月，观察组PFS均值显著高于对照组（P<0.05），但OS均值比较差异无统计学意义（P>0.05）；两组均有不同程度不良反应，观察组恶心、呕吐发生率高于对照组（P<0.05）；所有不良反应均经对症处理后缓解或消失，对患者治疗并无严重影响。结论 TACE治疗原发性肝癌的治疗效果显著，该治疗方式能有效改善患者的生存状态，增加患者的生存时间及生存率，故值得在临床实践中大力借鉴和推广。

[关键词]肝动脉化疗栓塞术；原发性肝癌；支持治疗；生存分析

[中图分类号] R735.7 [文献标识码] A [文章编号] 1674-4721（2018）5（b）-0066-03

Clinical study of hepatic arterial chemoembolization in the treatment of primary liver cancer

CHEN Zuo-bo1 LIU Qiu-fang2 HONG Ke-zhong1

1.Department of Internal Medicine，People′s Hospital of Shanwei City，Guangdong Province，Shanwei 516600，China；2.Physical Examination Center，People′s Hospital of Shanwei City，Guangdong Province，Shanwei 516600，China

[Abstract]Objective To investigate the clinical effect of hepatic arterial chemoembolization in the treatment of primary liver cancer.Methods A total of 100 patients with primary liver cancer who were admitted to our hospital from January 2010 to May 2014 were selected as the study subjects and randomly divided into observation group and control group，50 patients in each group.The patients in the observation group were treated with hepatic arterial chemoembolization for clinical treatment.The patients in the control group were treated with supportive therapy for clinical treatment.After the end of treatment，the clinical efficacy，progression-free survival（PFS），overall surviva（OS），and incidence rate of adverse reactions were observed and recorded in both groups，and comparative analysis was carried out.Results There was no significant difference in objective remission rate and disease control rate between the two groups（P>0.05）；the mean values of PFS and OS in the observation group was （11.25±0.84） months and （18.57±0.99） months respectively.The control group was （7.51±0.67） months and （17.03±0.89） months respectively.The comparative analysis showed that the observation group was significantly higher than that in the control group in terms of the mean value of PFS（P<0.05）.However，there was no significant difference in the mean value of OS（P>0.05）；both groups showed different degrees of adverse reactions.The incidence rate of nausea and vomiting was higher in the observation group than that in the control group （P<0.05）；all adverse reactions were relieved or disappeared after symptomatic treatment，and there was no serious effects on the treatment for patients.Conclusion Hepatic arterial chemoembolization has a significant therapeutic effect in the treatment of primary liver cancer.The treatment method can effectively improve the patient′s survival status，increase the patient′s survival time and survival rate，so it is worthy of learning and promotion in the clinical practice.

[Key words]Hepatic arterial chemoembolization；Primary liver cancer；Supportive treatment；Survival analysis

肝癌是肿瘤中常见的恶性肿瘤之一，且多数患者在疾病发现时已处于晚期，往往失去手术机会，从而预后较差。此时，姑息性治疗方法成为治疗原发性肝癌的重要手段。肝动脉化疗栓塞（transcatheter arterial chemo-emholization，TACE）是临床上不可切除肝癌的主要治疗方法[1]。本研究就TACE治疗原发性肝癌的临床效果进行了分析和探讨，特选择我院收治的100例原发性肝癌患者作为研究对象，现报道如下。

1资料与方法

1.1一般资料

选择2010年1月～2014年5月我院收治的100例原发性肝癌患者作为研究对象，入选患者均经临床诊断或病理确诊为原发性肝癌，同时随访资料完整，且排除存在淋巴结及其他脏器转移、经手术治疗及化疗禁忌患者，符合本研究的基本条件。随……