卡前列素氨丁三醇注射液防治子宫宫缩乏力性产后出血的临床效果

冯文丽 陈淡绵

[摘要]目的 觀察卡前列素氨丁三醇注射液防治子宫宫缩乏力性产后出血的临床疗效。方法 选择2016年9月～2017年9月在我院分娩的114例因宫缩乏力引起产后出血产妇作为研究对象，按随机数字表法分为对照组和观察组，每组各57例。胎儿娩出后，对照组给予缩宫素治疗，观察组给予卡前列素氨丁三醇注射液治疗。比较两组产妇产后0.5、0.5～1.5、1.5～24 h出血量；比较两组产妇产后24 h血红蛋白（Hb）下降值；比较两组产妇产后24 h血压、脉搏变化情况；观察两组药物不良反应情况。结果 观察组产妇产后0.5、0.5～1.5、1.5～24 h出血量显著少于对照组（P<0.05）；观察组产妇产后24 h Hb下降值低于对照组（P<0.05）；两组产后24 h各组血压、脉搏差异无统计学意义（P>0.05）；两组产妇用药后均未发生严重药物不良反应。结论 卡前列素氨丁三醇注射液在防治宫缩乏力性产后出血较缩宫素有明显的优势，显著减少了产后出血量，确保了产妇生命体征平稳，无严重不良反应，值得临床推广。

[关键词]产后出血；宫缩乏力；卡前列素氨丁三醇注射液；缩宫素

[中图分类号] R714.461 [文献标识码] A [文章编号] 1674-4721（2018）5（b）-0092-03

Clinical effect of Carboprost Tromethamine Injection in the prevention and treatment of uterine atony postpartum hemorrhage

FENG Wen-li CHEN Dan-mian

Department of Gynaecology and Obstetrics，Chaoan District People′s Hospital of Chaozhou City，Guangdong Province，Chaozhou 521000，China

[Abstract]Objective To observe the clinical effict of Carboprost Tromethamine Injection in the prevention and treatment of uterine atony postpartum hemorrhage.Methods Altogether 114 cases of pregnant women who gave birth in our hospital and suffered from postpartum hemorrhage caused by uterine atony from September 2016 to September 2017 were selected as the object of the research and divided into control group and observation group according to random number table method，57 cases in each group.After fetal childbirth，the control group was given oxytocin treatment，the observation group was received the treatment of Carboprost Tromethamine Injection.The hemorrhage of parturients at postpartum 0.5，0.5-1.5 and 1.5-24 h，the decrease value in hemoglobin （Hb）levels and changes in blood pressure and pulse at postpartum 24 h as well as drug adverse reactions were compared between two groups.Results The hemorrhage at postpartum 0.5，0.5-1.5 and 1.5-24 of observation group was significantly lower than that of control group （P<0.05）；the decrease value in hemoglobin （Hb） levels of observation group at postpartum 24 h was lower than that of control group （P<0.05）.No statistically significant difference was seen in the changes in blood pressure and pulse at postpartum 24 h between the two groups （P>0.05）；the two groups had no serious drug adverse reactions after treatment.Conclusion Carboprost Tromethamine Injection has more obvious advantages in prevention and treatment of postpartum hemorrhage due to uterine inertia than oxytocin，significantly reducing the amount of postpartum hemorrhage，ensuring the stable vital signs and no serious adverse reactions.It is worthy of clinical promotion.

[Key words]Postpartum hemorrhage；Uterine atony；Carboprost Tromethamine Injection；Oxytocin

产后出血是产妇分娩后常见的并发症，一直是发展中国家孕产妇死亡的主要原因，可继发休克、急性肾衰竭、弥散性血管内凝血（DIC）等严重并发症[1]。其主要原因与产后宫缩乏力密切相关[2]，因此，及时有效的增强子宫收缩是减少产后出血量的关键[3]。目前，临床常用的增强宫缩药物有缩宫素和卡前列素氨丁三醇注射液，为观察新药卡前列素氨丁三醇注射液在防治宫缩乏力性产后出血中是否比经典药物缩宫素具有优势，本研究采用两种药物进行比较，现报道如下。……