坤泰胶囊联合地屈孕酮治疗更年期综合征伴焦虑抑郁的临床研究

康幼红 周宏

[摘要]目的 分析坤泰胶囊与地屈孕酮联合治疗更年期综合征伴焦虑抑郁的临床效果。方法 按照随机数字表法将我院2015年3月～2016年6月接诊的更年期综合征伴焦虑抑郁患者80例分为对照组和观察组，每组各40例。对照组采用地屈孕酮治疗，观察组采用坤泰胶囊联合地屈孕酮治疗，观察并比较两组的临床治疗效果。结果 两组治疗前更年期Kupperman评分标准（K评分）、汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）评分比较，差异无统计学意义（P>0.05）；观察组治疗后K评分明显高与对照组（P<0.05）；观察组总有效率明显高与对照组（P<0.05）；治疗后，观察组HAMA、HAMD评分明显低于对照组，差异均有统计学意义（P<0.05）。结论 更年期综合征伴焦虑抑郁患者行坤泰胶囊与地屈孕酮联合治疗，临床效果明显，可明显提升患者的K评分，降低患者的HAMA及HAMD评分。

[关键词]坤泰胶囊；地屈孕酮；更年期综合征伴焦虑抑郁

[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721（2018）5（a）-0141-03

[Abstract]Objective To analyze the clinical efficacy of Kuntai Capsules combined with Dydrogesterone in the treatment of climacteric syndrome with anxiety and depression.Methods By a random number table，80 menopausal syndrome patients with anxiety and depression treated in our hospital from March 2015 to June 2016 were divided into control group and observation group.The control group was treated with Dydrogesterone and the observation group was treated Kuntai Capsules combined with Dydrogesterone respectively.The clinical therapeutic effect in the two groups were observed and compared.Results There was no significant difference in Kupperman （K） score，Hamilton Anxiety Rating Scale（HAMA） score or Hamilton Depression Scale （HAMD） score before treatment between the two groups （P>0.05）.After treatment，the K score was significantly higher in the observation group（P<0.05）.With regard to total effectiveness rate，the rate in the observation group was significantly higher compared with that in the control group （P<0.05）.After therapy，the HAMA and HAMD scores decreased significantly in the observation group in comparison with those in the control group，the differences were statistically significant （P<0.05）.Conclusion The combination of Kuntai Capsules and dydrogesterone for menopausal syndrome with anxiety and depression has a remarkable clinical effect on increasing K score，decreas HAMA and HAMD scores.

[Key words]Kuntai Capsules；Dydrogesterone；Menopausal syndrome with anxiety and depression

更年期綜合征因为雌激素水平变低而出现一些症状，使患者卵巢功能减弱，但垂体功能亢进，分泌更多促性腺激素，使自主神经功能处于无序状态[1]。基于此，治疗需调整患者阴阳与行补肾气[2-3]。更年期综合征较大程度影响女性身体各个系统，如神经系统、心血管系统及泌尿生殖系统，一般患者出现负面情绪，如焦虑抑郁等，往往表现为多种情绪波动，如头目眩晕、心烦易怒及失眠等[4]。对更年期综合征的治疗，为获得良好的效果，本研究采用坤泰胶囊与地屈孕酮联合治疗，现报道如下。

1资料与方法

1.1一般资料

研究对象为我院2015年3月～2016年6月诊治的80例更年期综合征伴焦虑抑郁患者，本研究通过我院医学伦理委员会同意，所有患者签订知情同意书。纳入标准：血清雌二醇<30 ng/L，促卵泡激素>20 U/L；中医阴虚火旺症。以……