经阴道彩色多普勒超声联合CA125+CA199在子宫内膜癌筛查中的临床价值

廖街平　李姣玲

【摘要】 目的：探讨经阴道彩色多普勒超声（TVCDS）联合CA125+CA199在子宫内膜癌筛查中的临床价值。方法：选取2016年1月-2017年12月于广东省水电医院就诊的80例子宫内膜癌作为研究对象，所有患者行TVCDS，发现子宫内膜可疑癌病灶均进一步行CA125+CA199检测，与病理診断结果对照。结果：TVCDS诊断Ⅰ～Ⅰc期、Ⅱ～Ⅳ期子宫内膜癌与病理的符合率分别为53.13%、100%；CA125+CA199诊断Ⅰ～Ⅰc期、Ⅱ～Ⅳ期子宫内膜癌与病理的符合率分别为50.00%、89.58%；TVCDS+CA125+CA199诊断Ⅰ～Ⅰc期、Ⅱ～Ⅳ期子宫内膜癌与病理的符合率分别为81.25%、100%。结论：TVCDS联合CA125+CA199诊断子宫内膜癌并进行分期，可提高Ⅰ～Ⅰc期子宫内膜癌的检出率以及与病理的符合率。

【关键词】 经阴道超声； 肿瘤标志物； 子宫内膜癌； 肿瘤分期

Clinical Value of Transvaginal Color Dopple Sonography Combined with CA125+CA199 in the Differentiation of Endometrial Carcinoma/LIAO Jieping，LI Jiaoling.//Medical Innovation of China，2018，15（16）：-122

【Abstract】 Objective：To investigate the clinical value of transvaginal color dopple sonography （TVCDS） combined with CA125+CA199 in the differentiation of endometrial carcinoma.Method：A total of 80 patients with endometrial carcinoma treated from January 2016 to December 2017 in Guangdong Hydropower Hospital were selected as study objects. TVCDS were performed in all patients，and the lesions of suspected endometrial carcinoma were further detected by CA125+CA199，which were compared with pathological diagnosis.Result：The coincidence rates between TVCDS in diagnosis of endometrial carcinoma in stage Ⅰ-Ⅰc and stage Ⅱ-Ⅳ with pathology were 53.13% and 100%，respectively；the coincidence rates between CA125+CA199 in diagnosis of endometrial carcinoma in stage Ⅰ-Ⅰc and stage Ⅱ-Ⅳ with pathology were 50.00% and 89.58%，respectively；the coincidence rates of TVCDS+CA125+CA199 in diagnosis of endometrial carcinoma in stage Ⅰ-Ⅰc and stage Ⅱ-Ⅳ with pathology were 81.25% and 100%，respectively.Result：TVCDS combined CA125+CA199 in the diagnosis and staging of endometrial carcinoma can improve the detection rate of endometrial carcinoma in stage Ⅰ-Ⅰc and the coincidence rate with pathology.

【Key words】 Transvaginal color dopple sonography； Tumor marker； Endometrial carcinoma； Tumor staging

First-authors address：Guangdong Hydropower Hospital，Guangzhou 511340，China

doi：10.3969/j.issn.1674-4985.2018.16.036

子宫内膜癌是一组发生于子宫内膜的上皮性恶性肿瘤，每年约有142 000例新发，42 000例病死[1]。现已成为危害世界公共卫生安全的严重问题，受到业界以及公共卫生层面的密切关注[2-3]。TVCDS是子宫内膜癌筛查的首选方法，然而对Ⅰ～Ⅰc期子宫内膜癌的检出率较低[4-6]。研究报道，TVCDS辅以血清肿瘤标志物检测可提高子宫内膜癌的检出率和临床分期的准确率[7-10]。目前，关于TVCDS联合CA125+CA199筛查子宫内膜癌的研究鲜有报道。为此，本院开展该研究旨在通过回顾性分析80例病理检查证实为子宫内膜癌患者的临床资料，探讨经阴道彩色多普勒超声联合CA125+CA199在子宫内膜癌筛查中的临床价值，并提出筛查以及早期诊断的策略。现报道如下。

1 资料与方法

1.1 一般资料 选取2016年1月-2017年12月在广东省水电医院就诊的80例子宫内膜癌患者作为研究对象，其中年龄28～76岁，平均（53.28±5.07）岁；……