斑蝥胶囊对乳腺癌内分泌治疗患者生命质量影响的临床研究

吴池华 李一 杨麟翰 贾新建

摘要 目的：探討斑蝥胶囊对乳腺癌内分泌治疗患者生命质量的影响。方法：选取2015年5月至2017年6月四川省人民医院收治的乳腺癌根治术后患者126例为研究对象，以随机数字表法分为对照组63例，观察组63例，对照组给予内分泌药物治疗，观察组在对照组基础上加用纯中药制剂斑蝥胶囊治疗，观察2组患者治疗前后生命质量、免疫功能变化及治疗期间不良反应发生情况。结果：生命质量治疗前2组差异无统计学意义（P>0.05），经治疗后，观察组FACT-B、EORTC-QOL-C30评分与对照组比较，均显著较高，差异有统计学意义（P<0.05）;免疫功能治疗前2组患者差异无统计学意义（P>0.05），经治疗后，观察组CD8+与对照组比较，明显较低，CD4+、CD4+/CD8+与对照组比较，显著较高，差异有统计学意义（P<0.05）;观察组治疗期间恶心、潮热、肌肉关节疼痛及阴道流血发生率分别为11.11%、7.94%、6.35%、3.17%，与对照组25.40%、20.63%、19.05%、14.29%比较，均明显较低，差异有统计学意义（P<0.05）。结论：在乳腺癌内分泌治疗中加入斑蝥胶囊，可有效提高患者免疫功能，减少不良反应，提高生命质量，值得推广。

关键词 乳腺癌;内分泌治疗;中药;斑蝥胶囊;生命质量

Clinical Study on the Effects of Cantharidis Capsule on the Quality of Life

of the Patients with Breast Cancer Endocrine Therapy

Wu Chihua1， Li Yi1， Yang Linhan1， Jia Xinjian2

（1 Department of Breast Surgery， Sichuan Provincial People′s Hospital， Chengdu 610000， China; 2 Department of Breast

Surgery， Sichuan Province Deyang People′s Hospital， Deyang 618000， China）

Abstract Objective：To investigate the effects of Cantharidis Capsule on the quality of life of the patients with breast cancer endocrine therapy. Methods：A total of 126 patients who received radical mastectomy from May 2015 to June 2017 were selected as the subjects. They were randomly divided into 63 cases in the control group and 63 cases in the observation group. The control group was given endocrine drug treatment. The observation group was treated with pure Chinese medicine preparation of Cantharidin Capsule on the basis of the control group. The quality of life， immune function changes and adverse reactions during treatment were observed in the two groups before and after treatment. Results：There was no significant difference in the quality of life between the two groups before treatment （P > 0.05）. After treatment， the scores of FACT-B and EORTC-QOL-C30 in the observation group were significantly higher than those in the control group. The difference was statistically significant （P<0.05）. There was no significant difference between the two groups before treatment （P>0.05）. After treatment， the CD.8+ in the observation group was significantly lower than that in the control group， and CD4+ and CD4+/CD.8+ were significantly higher than those in the control group. The difference was statistically significant （P<0.05）. The incidence of nausea， fever， muscle joint pain and vaginal bleeding in the observation group were 11.11%， 7.94%， 6.35% and 3.17%， respectively， which were significantly lower than those in the control group 25.40%， 20.63%， 19.05% and 14.29% （P<0.05）. Conclusion：Adding Cantharidin capsule to endocrine therapy of breast cancer can effectively improve the immune function， reduce adverse reactions and improve the quality of life， and is worthy of promotion.

Key Words Breast cancer; Endocrine therapy; Chinese medicine; Cantharidis capsule; Quality of life

中图分类号：R242;R737.9文献标识码：Adoi：10.3969/j.issn.1673-7202.2018.03.029

乳腺癌在临床较为常见，其发病率近年来呈上升趋势，有数据显示[1]，我国每年女性乳腺癌发病患者大16.9万，已成为严重公共卫生问题。手术结合科学放化疗方案，可达到根治效果，对延长患者存活时间具有积极意义。但有研究发现[2-3]，乳腺癌术后仍有复发风险，需给予合理治疗。乳腺癌内分泌治疗是预防术后复发有效方法，但其存在明显不良反应，对患者生命质量有较大影响。中医对乳腺癌治疗有丰富经验，本研究通过对比，探讨了斑蝥胶囊在乳腺癌内分泌治疗患者中的应用价值，报道如下。

1 资料与方法

1.1 一般资料 选取2015年5月至2017年6月收治的乳腺癌根治术后患者126例为研究对象，研究经伦理委员会审查并批准，以随机数字表法分组。观察……