李小惠
[摘要]目的 分析2型糖尿病患者发生结直肠腺瘤的危险因素。方法 选取2011年1月~2017年1月在本院被确诊为2型糖尿病合并结直肠腺瘤的患者2025例,设为观察组。同时段在本院治疗的2型糖尿病未发生结直肠腺瘤的患者2700例,设为对照组。比较两组的一般资料并进行多因素分析。结果 两组患者的性别,遗传、肥胖、高脂饮食率,多囊卵巢综合征发生率比较,差异均无统计学意义(P>0.05)。两组患者的合并疾病(高血压、冠心病)、代谢综合征发生率,糖化血红蛋白、餐后血糖水平比较,差异均有统计学意义(P<0.01)。多因素分析显示,代谢综合征、糖化血红蛋白水平、餐后血糖水平是2型糖尿病患者发生结直肠腺瘤的危险因素(P=0.000)。结论 代谢综合征、糖化血红蛋白水平、餐后血糖水平是2型糖尿病患者发生结直肠腺瘤的危险因素。
[关键词]2型糖尿病;结直肠腺瘤;危险因素
[中图分类号] R587.2 [文献标识码] A [文章编号] 1674-4721(2018)9(a)-0060-03
[Abstract] Objective To analyze the risk factors of colorectal adenoma occurrence in patients with type 2 diabetes mellitus. Methods A total of 2025 patients with type 2 diabetes mellitus complicated with colorectal adenoma diagnosed by our hospital from January 2011 to January 2017 were set as the observation group and 2700 patients with type 2 diabetes mellitus having no colorectal adenoma treated in our hospital at the same time were set as the control group. The general data between the two groups were compared and multivariate analysis was performed. Results There were no significant differences in gender, the rate of heredity, obesity, high fat diet rate and the incidence of polycystic ovary syndrome between the two groups (P>0.05). Multivariate analysis showed that metabolic syndrome, glycosylated hemoglobin and postprandial blood glucose were risk factors for colorectal adenoma in type 2 diabetic patients (P=0.000). Conclusion Metabolic syndrome, glycosylated hemoglobin and postprandial blood glucose were risk factors for type 2 diabetic patients complicated with colorectal adenoma.
[Key words] Type 2 diabetes mellitus; Colorectal adenoma; Risk factors
全球范圍内结直肠腺瘤的发病率逐渐呈上升趋势,在西方发达国家其发病率居恶性肿瘤的第2~3位,而我国结直肠腺瘤的发病率居第3~5位[1-3]。结直肠腺瘤的发病原因较多,只有找出结直肠腺瘤的诱因并采取相应的预防措施,才能降低结直肠腺瘤的发病率[4-5]。有研究显示,2型糖尿病也是结直肠腺瘤的高危诱发原因之一[6-8]。2型糖尿病是一种慢性疾病,随着病程的延长,容易诱发其他疾病,而多种疾病的融合会遮盖消化系统肿瘤的临床表现。本研究回顾分析了2型糖尿病患者发生结直肠腺瘤的有关因素,以便帮助其及早识别危险致病因素,进行结肠镜筛查,早期发现结直肠腺瘤。
1 资料与方法
1.1 一般资料
选取2011年1月~2017年1月在本院被确诊为2型糖尿病患者合并结直肠腺瘤的患者2025例,设为观察组,其中男1278例,女747例;年……