NLR、血清胱抑素C及IL-6检测在冠心病患者中的应用价值

张起 刘伟 徐艳平 熊家旭

[摘要] 目的 探討NLR、CysC及IL-6联合检测在冠心病患者中的应用价值。 方法 选取本院在2016年6月～2018年6月住院的85例冠心病患者作为研究对象，选取同期40例健康人群作为对照组，对两组的血清中性粒细胞与淋巴细胞比值（NLR）、血清胱抑素C（CysC）、白细胞介素6（IL-6）水平进行分析测定，并对结果进行分析。同时测定患者总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等生化指标，并对结果进行分析。 结果 冠心病患者的NLR、CysC、IL-6检测水平明显高于对照组，差异有统计学意义（P<0.05）。在冠心病患者中又以急性心肌梗死的NLR、CysC及IL-6各项检测值最高，稳定型心绞痛（SAP）各项检测值相对最低，且三组间检测水平差异有统计学意义（P<0.05）。 结论 NLR、CysC、IL-6在冠心病尤其是急性心肌梗死中显著升高，可作为冠心病的评价指标之一。

[关键词] 冠心病;中性粒细胞与淋巴细胞比值;血清胱抑素C;白细胞介素6

[中图分类号] R446          [文献标识码] B          [文章编号] 1673-9701（2020）17-0148-03

Application value of NLR， serum cystatin C and IL-6 detection in the patients with coronary heart disease

ZHANG Qi   LIU Wei   XU Yanping   XIONG Jiaxu

Department of Clinical Laboratory，Yichun Second People's Hospital in Jiangxi Province，Yichun   336000，China

[Abstract] Objective To explore the application value of NLR， serum cystatin C and IL-6 combined detection in the patients with coronary heart disease （CHD）. Methods 85 patients with CHD hospitalized in our hospital from June 2016 to June 2018 were selected as the subjects of research， and 40 healthy people were selected as the control group at the same time. The serum neutrophil-to-lymphocyte ratio（NLR）， serum cystatin C（CysC） and interleukin 6（IL-6） levels of the two groups were analyzed and determined， and the results were analyzed. Meanwhile， the biochemical indexes such as total cholesterol （TC）， triglyceride （TG）， high density lipoprotein cholesterol （HDL-C）， low density lipoprotein cholesterol （LDL-C） and so on were determined， and the results were analyzed. Results The levels of NLR， serum CysC， IL-6 in the patients with CHD were significantly higher than those in the control group， and there were significant differences between the two groups（P<0.05）. Among the patients with CHD， the detection values of NLR， CysC and IL-6 of the patients with acute myocardial infarction （AMI） were the highest， while those of the patients with stable angina pectoris（SAP） were the lowest， and the detection levels among the three groups were significantly different with statistical significance（P<0.05）. Conclusion NLR， CysC， IL-6 are significantly increased in the patients with CHD， especially AMI. They might be used among the evaluation indexes of CHD.

[Key words] Coronary heart disease（CHD）; Neutrophil-to-lymphocyte ratio（NLR）; Serum cystatin C（CysC）; Interleukin-6（IL-6）

冠心病（Coronary heart disease，CHD）是全球性的危害健康的疾病，近年来我国冠心病发病率已呈逐年上升趋势，给社会带来的经济负担日趋加重，冠心病将是我国需要重点关注的公共卫生问题[1-2]。因此，提高冠心病的早期诊断效率并积极地进行干预，具有非常重要的临床意义。目前诊断冠状动脉狭窄的金标准为冠状动脉造影（Coronary angiography，CAG），但因其有创性、风险性及较高的成本，导致其在冠心病筛查中比较难以普及实施，探究无创的、更加高效的检查方式对医学研究有着重大意义。近年来NLR、CysC及IL-6在各方面的研究讨论越来越多，在冠心病检测方面也各自有所涉猎[3-4]，但三者同时在冠心病患者中应用的价值探讨还很少，本研究希望能通过对NLR、CysC及IL-6在CHD患者中的检测水平变化，探讨三者在临床诊断和治疗效果中的价值。……