郑方方



摘 要 目的:探讨普罗帕酮联合电复律治疗心律失常患者炎性因子水平和康复预后的价值。方法:将102例心律失常患者依据随机数字表法分为对照组和观察组各51例。对照组给予胺碘酮治疗,观察组给予普罗帕酮联合电复律治疗,对比两组治疗效果及治疗前后血清超敏C反应蛋白(hs-CRP)、心率变异性(HRV)指标变化情况及不良反应等。结果:观察组治疗总有效率为96.1%,明显高于对照组的78.4(P<0.05),且治疗后观察组血清hs-CRP低于对照组,HRV指标均高于对照组(P<0.05)。结论:普罗帕酮联合电复律治疗心律失常患者能有效提高治疗效果,改善患者心率变异性,降低炎性因子水平。
关键词 普罗帕酮 电复律 心律失常 炎性因子 心率变异性
中图分类号:R972.2; R541.7 文献标志码:A 文章编号:1006-1533(2021)03-0027-03
The value of propafenone combined with electrocardioversion in the treatment of inflammatory factors of patients with arrhythmia and the effect on their rehabilitation prognosis
ZHENG Fangfang
(Department of Cardiology, the Second Peoples Hospital of Pingdingshan City, Henan Pingdingshan 467000, China)
ABSTRACT Objective: To investigate the value of propafenone combined with electrocardioversion in the treatment of inflammatory factors of patients with arrhythmia and the effect on their rehabilitation prognosis. Methods: One hundred and two patients with arrhythmia were randomly divided into a control group and an observation group. The control group was treated with amiodarone while the observation group with propafenone combined with electrocardioversion. The therapeutic effect, changes of serum hs-CRP and heart rate variability (HRV) before and after treatment were compared between the two groups. Results: The overall response rate was significantly higher in the observation group than the control group (96.1% vs 78.4%, P<0.05). After treatment, the serum hs-CRP was lower and the indexes of HRV were higher in the observation group than the control group (P<0.05). Conclusion: Propafenone combined with electrocardioversion can improve the therapeutic effect and the HRV and decrease the levels of inflammatory factors in patients with arrhythmia.
KEY WORDS propafenone; cardioverter; arrhythmia; inflammatory factors; heart rate variability
心律失常是指人體心脏的冲动频率、传导速度及节律发生异常改变,为临床常见心血管疾病之一,该病多发生于成年人[1]。临床根据心率的快慢将心律失常分为快速性和缓慢性两种,其中快速性心律失常表现为心房颤动、过早搏动、心动过速等,而缓慢性心律失常则表现为窦性缓慢性心律失常以及各种传导阻滞等。若不及时进行干预,心律失常可造成血流动力学紊乱,引起心力衰竭等,严重时甚至增加患者的病死率[2-4]。研究表明在心律失常患者中其血清超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)呈现较高表达,可见血清hsCRP对心律失常有明显促进作用[5]。胺碘酮、普罗帕酮为临床常用抗心律失常药物,选择合适有效的药物治疗对改善患者预后具有重要意义。本研究采用普罗帕酮联合电复律治疗心律失常患者,获得较好效果。
1 资料与方法
1.1 临床资料
选取我院2018年7月—2019年10月间收治的心律失常患者102例作为研究对象,依据随机数字表法分为对照组和观察组各51例。……