基于“无虚不作痫”理论治疗痫病的临床疗效评价

洪荣庆 黎胜驹 李玉红 李莲英 关锦贞 陈瑶

【摘要】 目的：探究基于“無虚不作痫”的理论，采用清心汤辨证加减联合丙戊酸钠缓释片应用于痫病的临床效果。方法：选取2019年1月1日-2020年9月1日阳江市中医医院80例癫痫患者，采用随机数字表法将其分为对照组与治疗组，每组40例。对照组采用丙戊酸钠缓释片治疗，治疗组采用清心汤辨证加减联合丙戊酸钠缓释片治疗。比较两组不良反应发生情况，治疗8、16周和治疗后8、16周的疗效，治疗前后症候积分、癫痫症状周发作频次及持续时间。结果：治疗8、16周及治疗后8、16周，治疗组总有效率均高于对照组，差异均有统计学意义（P<0.05）。治疗前，两组症候积分比较，差异无统计学意义（P>0.05）;治疗后，两组症候积分均低于治疗前，且治疗组低于对照组，差异均有统计学意义（P<0.05）。治疗前，两组癫痫周发作频次、发作持续时间比较，差异均无统计学意义（P>0.05）;治疗后，两组癫痫周发作频次及发作持续时间均少于治疗前，且治疗组均少于对照组，差异均有统计学意义（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：基于“无虚不作痫”的理论，采用清心汤辨证加减联合丙戊酸钠缓释片治疗痫病效果显著，可改善患者临床症状，安全性高，值得应用与推广。

【关键词】 癫痫 无虚不作痫 清心汤 丙戊酸钠缓释片

Evaluation of the Clinical Efficacy of the Treatment of Epilepsy Based on the Theory of “No-deficiency， No Epilepsy”/HONG Rongqing， LI Shengju， LI Yuhong， LI Lianying， GUAN Jinzhen， CHEN Yao. //Medical Innovation of China， 2021， 18（29）： 0-094

[Abstract] Objective： To explore the clinical effect of Qingxin Decoction syndrome differentiation modified and Sodium Valproate Sustained-release Tablets in epilepsy based on the theory of "no-deficiency， no epilepsy". Method： A total of 80 patients with epilepsy in Yangjiang Hospital of Traditional Chinese Medicine from January 1， 2019 to September 1， 2020 were selected， and they were divided into control group and treatment group according to random number table method， 40 patients in each group. The control group was treated with Sodium Valproate Sustained-release Tablets， and the treatment group was treated with Qingxin Decoction syndrome differentiation modified combined with Sodium Valproate Sustained-release Tablets. The incidence of adverse reactions and the efficacy of 8， 16 weeks of treatment and 8， 16 weeks after treatment， syndrome scores before and after treatment， weekly frequency and duration of epilepsy were compared between two groups. Result： 8， 16 weeks of treatment and 8， 16 weeks after treatment， the total effective rate of the treatment group were higher than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there was no significant difference in syndrome scores between two groups （P>0.05）; after treatment， the syndrome scores of both groups were lower than those before treatment， and that of the treatment group was lower than that of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in the weekly frequency and duration of epilepsy between two groups （P>0.05）; after treatment， the weekly frequency and duration of epilepsy of both groups were less than those before treatment， those of the treatment group were less than those of the control group， the differences were statistically significant （P<0.05）. There was no significant difference in the incidence of adverse reactions between two groups （P>0.05）. Conclusion： Based on the theory of “no-deficiency， no epilepsy”， the Qingxin Decoction syndrome differentiation modified combined with Sodium Valproate Sustained-release Tablets has a significant effect on the treatment of epilepsy， it can improving the clinical symptoms of patients and has high safety， which is worthy of application and promotion.

[Key words] Epilepsy No-deficiency， no epilepsy Qingxin Decoction Sodium Valproate Sustained-release Tablets

First-author’s address： Yangjiang Hospital of Traditional Chinese Medicine， Yangjiang 529500， China

doi：10.3969/j.issn.1674-4985.2021.29.022

癫痫是临床工作中常见疾病，是一种由多原因导致的脑神经元同步化异常放电所致的突然性、反复性和短暂性的运动、感觉、意识、精神和自主神经等功能异常的脑部疾病，发病机制较为复杂[1-3]。……