纳洛酮联合胞磷胆碱治疗脑梗死效果的Meta分析

张树丹 李琪

【摘要】 目的：系统评价纳洛酮联合胞磷胆碱治疗脑梗死的效果及安全性。方法：全面检索PubMed、Cochrane Library、Embase、SinoMed、知网、万方及维普医药在线数据库创库至2020年12月3日关于纳洛酮联合胞磷胆碱治疗脑梗死的随机对照试验（RCT），并追溯所纳入研究的参考文献，由两位研究人员根据纳入与排除标准各自对全部研究进行筛选与评价，然后提取数据，达成共识后运用RevMan 5.4软件统计分析。结果：纳入17篇文献，共1 359例患者，经Meta分析表明：联合治疗组脑梗死疗效优于常规治疗组[OR=6.04，95%CI（2.66，13.71），P<0.000 1）]，亦优于胞磷胆碱组[OR=5.31，95%CI（3.71，7.61），P<0.000 01）]。各组均未发生严重不良反应。结论：纳洛酮联合胞磷胆碱治疗脑梗死效果显著，安全性较好。

【关键词】 纳洛酮 胞磷胆碱 脑梗死 Meta分析

Naloxone Combined with Citicoline in the Treatment of Cerebral Infarction： a Meta-analysis/ZHANG Shudan， LI Qi. //Medical Innovation of China， 2021， 18（27）： -156

[Abstract] Objective： To review systematically the curative effect and safety of Naloxone combined with Citicoline in the treatment of cerebral infarction. Method： The databases of PubMed， Cochrane Library， Embase， SinoMed， CNKI， WanFang and VIP medicine were retrieved for collecting randomized controlled trials about Naloxone combined with Citicoline in the treatment of cerebral infarction before December 3， 2020， and reference lists were also searched. According to the inclusion and exclusion criteria， two reviewers screened and assessed independently the potential studies， and then the data was extracted， the data was given a Meta-analysis by using RevMan 5.4 software after consensus. Result： A total of 17 literatures were included， involving 1 359 patients. Meta-analysis showed： the clinical curative effect of the combination group in treating cerebral infarction was better than those of routine treatment group [OR=6.04， 95%CI （2.66， 13.71）， P<0.000 1] and Citicoline group [OR=5.31， 95%CI （3.71， 7.61）， P<0.000 01]. There were no serious adverse reactions in each groups. Conclusion： Naloxone combined with Citicoline in the treatment of cerebral infarction has significant curative effect， and the safety is good.

[Key words] Naloxone Citicoline Cerebral infarction Meta-analysis

First-author’s address： Dalian Hospital of Traditional Chinese Medicine， Dalian 116013， China

doi：10.3969/j.issn.1674-4985.2021.27.038

腦梗死系由不同原因所致的局部脑组织血液供应障碍，造成脑组织缺血、缺氧、坏死，进而产生神经功能缺失的临床表现[1]，如面瘫、言语不清、认知障碍、猝然昏倒、半身不遂、深度昏迷等。脑梗死是脑血管疾病中最为常见的类型，对人类的生命健康造成了极大的威胁，极大地影响了患者的生活质量，给患者家庭乃至社会带来沉重的经济负担。本文旨在系统评价纳洛酮联合胞磷胆碱治疗脑梗死的临床疗效和安全性，为临床选择药物治疗方案提供依据。现报道如下。

1 材料与方法

1.1 文献纳入、排除标准 （1）纳入标准：①中英文文献;②随机对照试验;③脑梗死;④联合治疗组为纳洛酮联合胞磷胆碱;⑤对照组为其他药物;⑥考察指标为临床疗效和不良反应。（2）排除标准：①未完成或提前终止;②缺失数据较多;③多次报道，仅纳入最新且数据最全的报告。……