2型糖尿病患者微炎性状态与血管功能状态的关系探究

付春娟

【摘要】 目的：探究2型糖尿病患者微炎性状态与血管功能状态的关系。方法：选取2019年1月-2021年1月本院80例2型糖尿病患者为观察组，另选取同期本院80名健康体检者为对照组。比较两组的血清微炎性状态指标（CRP及TNF-α）与血管功能状态指标（脉搏波传导速度指标及血清血管内皮损伤指标）;比较观察组中不同血糖不稳定指数（GLI）水平者的血清微炎性状态与血管功能状态指标。采用Pearson相关系数分析血清微炎性状态指标与血管功能状态指标的关系。结果：观察组各项血清微炎性状态指标、脉搏波传导速度指标及血管内皮损伤指标均高于对照组，差异均有统计学意义（P<0.05）。观察组中不同GLI水平者的各项血清微炎性状态指标、脉搏波传导速度指标及血管内皮损伤指标比较，差异均有统计学意义（P<0.05），GLI水平越高者各項血清微炎性状态指标、脉搏波传导速度指标及血管内皮损伤指标越高（P<0.05）。Pearson相关性分析显示，各项血清微炎性状态指标与各项脉搏波传导速度指标、血管内皮损伤指标均呈正相关（P<0.05）。结论：2型糖尿病患者的血清微炎性状态指标与血管功能状态指标均显著升高，且两者之间具有密切的关系，因此应重视对2型糖尿病患者上述方面的监测与调控。

【关键词】 2型糖尿病 微炎性状态 血管功能状态

[Abstract] Objective： To explore the relationship between micro-inflammatory state and vascular function state of patients with type 2 diabetes mellitus. Method： A total of 80 patients with type 2 diabetes mellitus in our hospital from January 2019 to January 2021 were selected as the observation group， and another 80 healthy subjects were selected as the control group. Serum micro-inflammatory status indexes （CRP and TNF-α） and vascular function status indexes （pulse wave conduction velocity indexes and serum vascular endothelial injury indexes） were compared between the two groups; the serum micro-inflammatory status and vascular function status indexes of patients with different blood glucose instability index （GLI） levels in the observation group were compared. Pearson correlation coefficient was used to analyze the relationship between serum micro-inflammatory status indexes and vascular function status indexes. Result： The serum micro-inflammatory status indexes， pulse wave conduction velocity indexes and vascular endothelial injury indexes in the observation group were higher than those in the control group， and the differences were statistically significant （P<0.05）. In the observation group， there were statistically significant differences in serum micro-inflammatory status indexes， pulse wave conduction velocity indexes and vascular endothelial injury indexes among patients with different GLI levels （P<0.05）. The higher the GLI level was， the higher the serum micro-inflammatory status indexes， pulse wave conduction velocity indexes and vascular endothelial injury indexes （P<0.05）. Pearson correlation analysis showed that the serum micro-inflammatory status indexes were positively correlated with pulse wave conduction velocity and vascular endothelial injury indexes （P<0.05）. Conclusion： The serum micro-inflammatory status indexes and vascular function status indexes of type 2 diabetes mellitus patients are significantly increased， and there is a close relationship between the two， so it is necessary to pay attention to the monitoring and regulation of the above aspects in type 2 diabetes mellitus patients.

[Key words] Type 2 diabetes mellitus Micro-inflammatory status Vascular function status

First-author’s address： The First Hospital of Dandong City， Dandong 118000， China

doi：10.3969/j.issn.1674-4985.2021.25.026

2型糖尿病在我国具有极高的发病率，而本病对患者机体多方面的危害显著，是临床的研究重点。临床研究认为，2型糖尿病患者普遍存在微炎性反应的情况，CRP及TNF-α是表达相对较高的微炎性状态指标[1-2]。……