丁苯酞对急性脑梗死患者血液黏度及趋化因子的影响探究

姜如海

【摘要】 目的：探究丁苯酞對急性脑梗死患者血液黏度及趋化因子的影响。方法：选取2018年10月-2020年6月98例急性脑梗死患者，根据随机数字表法将其分为对照组和观察组，每组50例。对照组进行常规脑梗死治疗，观察组则在对照组的基础上加用丁苯酞。比较两组疗效、治疗前后的全血黏度、全血还原黏度及血清趋化因子（CXCL4、CXCL12、CXCL16）。结果：观察组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前，两组的全血高切黏度、全血中切黏度、全血低切黏度、全血高切还原黏度、全血中切还原黏度、全血低切还原黏度、CXCL4、CXCL12、CXCL16比较，差异均无统计学意义（P>0.05）;治疗1、2周后，两组的全血高切黏度、全血中切黏度、全血低切黏度、全血高切还原黏度、全血中切还原黏度、全血低切还原黏度、CXCL4、CXCL12、CXCL16均低于治疗前，且观察组均低于对照组，差异均有统计学意义（P<0.05）。结论：丁苯酞在急性脑梗死患者中的应用效果较好，且可改善患者的血液黏度及趋化因子，在急性脑梗死患者中的应用价值较高。

【关键词】 丁苯酞 急性脑梗死 血液黏度 趋化因子

[Abstract] Objective： To investigate the influence of Butylphthalide for blood viscosity and chemokines in patients with acute cerebral infarction. Method： A total of 98 patients with acute cerebral infarction from October 2018 to June 2020 were selected， and they were divided into control group and observation group according to the method of random number table， 50 cases in each group. The control group was treated with routine treatment for cerebral infarction， the observation group was treated with Butylphthalide on the treatment of control group. The efficacy was compared between two groups， the whole blood viscosity， reduced blood viscosity and serum chemokines （CXCL4， CXCL12， CXCL16） before and after treatment were compared between two groups. Result： The total effective rate of the observation group was higher than that of the control group， and the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in the whole blood high tangent viscosity， whole blood medium tangent viscosity， whole blood low tangent viscosity， whole blood high tangent reduced viscosity， whole blood medium tangent reduced viscosity， whole blood low tangent reduced viscosity， CXCL4， CXCL12， and CXCL16 between two groups （P>0.05）; after 1 and 2 weeks of treatment， the whole blood high tangent viscosity， whole blood medium tangent viscosity， whole blood low tangent viscosity， whole blood high tangent reduced viscosity， whole blood medium tangent reduced viscosity， whole blood low tangent reduced viscosity， CXCL4， CXCL12 and CXCL16 of both groups were lower than those before treatment， and those of the observation group were lower than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： The application effect of Butylphthalide in the treatment of patients with acute cerebral infarction is better， and it can improve the blood viscosity and chemokines of patients， so its application value in the patients with acute cerebral infarction is higher.

[Key words] Butylphthalide Acute cerebral infarction Blood viscosity Chemokines

First-author’s address： Xingcheng People’s Hospital， Xingcheng 125100， China

doi：10.3969/j.issn.1674-4985.2021.25.027

急性脑梗死在我国发病率较高，且呈现大幅度升高的趋势，而本病的致残率及致死率极高，是临床研究的重点[1-2]。本病患者除表现出神经损伤及相关指标的异常外，血液黏度也多呈现较高的状态，影响循环，而趋化因子在本类患者中也呈现升高状态，故对其治疗的过程中，上述方面的控制均是疗效评估的重要方面[3-5]。本研究就丁苯酞注射液对急性脑梗死患者血液黏度及趋化因子的影响进行探究，现报道如下。……