非洛地平缓释片联合百令胶囊治疗慢性肾脏病对改善肾功能指标的影响

朱远亭 陈欣 唐雪敏 尹飞 王少良

摘要 目的：探析慢性肾脏病患者采取非洛地平缓释片联合百令胶囊治疗对改善肾功能指标的效果。方法：选取2016年11月至2020年7月芜湖市第一人民医院收治的慢性肾脏病患者60例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组30例。对照组采用非洛地平缓释片治疗，观察组采用非洛地平缓释片联合百令胶囊治疗，比较2组患者尿素氨（BUN）水平、血肌酐（SCr）、24 h尿蛋白定量、胱抑素C（Cys-C）、血清降钙素原（PCT）、超敏C反应蛋白（hs-CRP）以及治疗有效率等指标。结果：观察组患者的BUN、SCr、24 h尿蛋白定量、Cys-C等肾功能水平降低幅度明显大于对照组，差异有统计学意义（P<0.05）;观察组患者PCT、hs-CRP等炎症介质水平降低幅度明显大于对照组，差异有统计学意义（P<0.05）;观察组、对照组治疗有效率分别为96.67%、76.67%，观察组治疗有效率明显高于对照组，差异有统计学意义（P<0.05）。结论：慢性肾脏病患者采取百令胶囊联合非洛地平缓释片进行治疗在改善肾功能、炎症介质方面有着非常明显的优势，还可提升治疗有效率，对改善患者治疗预后有着明显的优势，应推广应用。

關键词 慢性肾脏病;非洛地平缓释片;百令胶囊;肾功能;炎症;治疗效果

Abstract Objective：To explore the effect of felodipine sustained-release tablets combined with Bailing Capsule on improving renal function in patients with chronic kidney disease.Methods：A total of 60 patients with chronic kidney disease admitted to Wuhu First People′s Hospital from November 2016 to July 2020 were selected as the research objects and were randomly divided into a control group（n=30） and an observation group（n=30） according to the random number method.The control group was treated with felodipine sustained-release tablets，and the observation group was treated with felodipine sustained-release tablets combined with Bailing Capsules.Urea ammonia（BUN） level，serum creatinine（SCr），24-hour urinary protein，Cystatin C（Cys-C），serum procalcitonin（PCT），high sensitivity C-reactive protein（hs CRP） and total effective rate were compared between the 2 groups.Results：The observation group patients′ BUN，SCr，24 h urine protein quantification，Cys-C and other renal function levels decreased significantly than the control group（P<0.05）; observation group patients′ PCT，hs-CRP and other inflammatory mediator levels decreased significantly greater than the control group（P<0.05）; The effective rates of treatment in the observation group and control group were 96.67% and 76.67%，respectively，and the effective rates of treatment in the observation group were significantly higher than those in the control group（P<0.05）.Conclusion：The treatment of patients with chronic kidney disease with Bailing Capsules combined with felodipine sustained-release tablets has obvious advantages in improving renal function and inflammatory mediators.It can also increase the efficiency of treatment and has obvious advantages in improving the prognosis of patients.The application should be promoted.

Keywords Chronic kidney disease; Felodipine sustained release tablets; Bailing Capsules; Renal function; Inflammation; Therapeutic effect

中图分类号：R289.5;R692文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.11.021

慢性肾脏病（Chronic Kidney Disease，CKD）作为慢性肾脏损伤的临床疾病，主要是由于各方面继发性肾脏病或者原发性肾脏病引起的疾病，有着进展缓慢、起病隐匿等基本特征[1]。CKD早期临床症状由于原发疾病的不同而有一定的差别，肾功能的恶化以及疾病的进展，会向尿毒症进展，从而对患者的生命安全产生威胁。CKD的逐渐发展，会造成间质纤维化、肾小管萎缩、肾小球硬化等病理变化，从而造成终末期肾脏病[2]。目前，临床对于CKD的治疗主要是促使慢性肾功能不全的进展、发展得到有效延缓。非洛地平缓释片是较为常见的一种西医治疗药物，作为二氢吡啶类钙离子通道阻滞剂，对血管平滑肌钙离子电流能起到阻断的作用，促使长效降压效果得到全面发挥[3]。……