磁共振弥散加权成像对肝脏局灶性良恶性病变的鉴别价值研究

2021-08-11 01:24:52张德龙京芳华
上海医药 2021年12期

张德龙 京芳华

摘 要 目的:探討磁共振弥散加权成像对肝脏局灶性良恶性病变的鉴别价值。方法:选择2019年5月—年2020月5月江西省宜春市中医院接诊的肝脏局灶性病变患者58例,所有患者均接受磁共振成像(magnetic resonance imaging,MRI)常规序列与弥散加权成像(diffusion weighted imaging,DWI)检查,比较不同病变性质DWI检查在不同扩散敏感系数(diffusion sensitivity coefficient,b值)时的表观弥散系数(apparent diffusion coefficient,ADC值)。以病理检查结果为金标准,比较MRI常规序列与DWI诊断肝脏局灶性恶性病变的效果。结果:b值分别为500 s/mm2、1 000 s/mm2、1 500 s/mm2时肝脏局灶性良性病变ADC值均高于肝脏局灶性恶性病变(P<0.05);在肝脏局灶性恶性病变诊断中DWI的特异度为94.74%、准确率为91.38%、阳性预测值为97.22%,高于MRI常规序列检查的68.42%、72.41%和82.86%(P均<0.05)。结论:DWI检查对肝脏局灶性良恶性病变的鉴别效果优于MRI常规序列检查,多b值DWI检查在肝脏良恶性病变的鉴别诊断方面有重要价值。

关键词 肝脏局灶性病变;磁共振弥散加权成像;MRI常规序列

中图分类号:R445.2 文献标志码:A 文章编号:1006-1533(2021)12-0030-03

Study of the value of magnetic resonance diffusion weighted imaging in differential diagnosis of focal benign and malignant liver lesions

ZHANG Delong, JING Fanghua

(Radiology Department of Traditional Chinese Medicine Hospital of Yichun, Jiangxi 336000, China)

ABSTRACT Objective: To investigate the value of magnetic resonance diffusion weighted imaging in the differential diagnosis of focal benign and malignant liver lesions. Methods: Fifty-eight patients with focal liver lesions were selected from May 2019 to May 2020 in Traditional Chinese Medicine Hospital of Yichun in Jiangxi Province, all patients underwent magnetic resonance imaging (MRI) routine sequence and diffusion weighted imaging(DWI) examinations, and the apparent diffusion coefficient(ADC value) with different diffusion sensitivity coefficient(b value) in DWI examination of different lesion properties was compared. The pathological examination results were used as the gold standard to compare the effectiveness of MRI routine sequence and DWI in diagnosing focal malignant liver lesions. Results: When the b values were 500 s/mm2, 1 000 s/mm2, and 1 500 s/mm2, the ADC values of focal benign liver lesions were higher than those of focal malignant liver lesions(P<0.05); in the diagnosis of focal liver malignant lesions, the specificity of DWI was 94.74%, the accuracy was 91.38%, and the positive predictive value was 97.22%, which was higher than the 68.42%, 72.41% and 82.86% of routine MRI sequence examinations (all P<0.05). Conclusion: DWI is better than MRI routine sequence examination in distinguishing focal benign and malignant liver lesions, and multi-b value DWI has important value in the differential diagnosis of benign and malignant liver lesions.

KEY WORDS focal hepatic lesion; magnetic resonance diffusion weighted imaging; MRI routine sequence

临床研究表明肝脏局灶性恶性病变缺乏典型的临床表现和影像学特征,极大地增加了早期诊断难度[1]。因此,肝脏局灶性病变的良恶性诊断鉴别一直是临床研究热点。近几年,随着国内磁共振成像(magnetic resonance imaging,MRI)技术的发展,肝脏局灶性恶性病变的漏诊率和误诊率大幅度下降[2]。磁共振弥散加权成像(diffusion weighted imaging,DWI)是一种能反映细胞水平组织变化、肿瘤细胞构成、细胞膜完整性的无创影像检查手段,表观弥散系数(apparent diffusion coefficient,ADC值)随病症演变呈现一定规律,能够体现疾病变化进程,临床应用效果优于MRI常规序列,在肝脏局灶性病变的良恶性鉴别中效果更佳[3-4]。本院对DWI与MRI常规序列检查在肝脏局灶性病变良恶性鉴别方面进行了對比研究。

1 资料与方法

1.1 一般资料

选择2019年5月—2020年5月江西省宜春市中医院接诊的肝脏局灶性病变患者58例,入院前未接受过放化疗或手术治疗等任何方式的治疗,并经病理诊断明确良性或恶性。……

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