中西医结合治疗小儿过敏性咳嗽的Meta分析

易晚秋 朱沁泉 张涤

【摘 要】 目的：对中西医结合治疗小儿过敏性咳嗽进行Meta分析。方法：研究者通过计算机全面检索知网、维普、万方数据库、Pubmed和Web of Science数据库，纳入中西医结合治疗与西药治疗小儿过敏性咳嗽的临床随机对照试验。检索时限为建库至2020年7月1日。采用RevMan5.3软件对纳入的文献进行Meta分析。结果：纳入8个RCT试验，共643例患者。Meta分析结果示：中西医结合治疗小儿过敏性咳嗽在提高总有效率、改善中医证候积分、减轻咳嗽频率和程度等方面均优于单纯西药组（P<0.05）。结论：中西医结合治疗小儿过敏性咳嗽疗效优于西药，疗效肯定，可为临床提供参考。

【关键词】 过敏性咳嗽;变应性咳嗽;中西医结合;Meta分析

【中图分类号】R256.11 【文献标志码】 A 【文章编号】1007-8517（2021）13-0075-04

Abstract：Objective Meta-analysis of integrated traditional Chinese and western medicine in the treatment of children with atopic cough.Methods The researchers comprehensively searched the CNKI，VIP， Wanfang Database， Pubmed and Web of Scienc Database by computer，and included them in the clinical randomized controlled trial of integrated traditional traditional Chinese and western medicine in the reatment of pediatric atopic cough.The retrieval time is from the date of database construction to July 1，2020.Meta analysis of the literature was performed using RevMan 5.3 software.Results A total of 643 patients were enrolled in 8 RCTs.The results of meta-analysis showed that the integrated TCM and western medicine treatment of AC was superior to the western medicine group in improving the total effective rate， improving the integral of TCM syndromes，and reducing the frequency and degree of coughs（P<0.05）.Conclusions The combination of trational Chinese and western medicine is more effective than western medicine in the reatment of pediatric atopic cough.

Keywords：Atopic Cough;Allergic Cough; Integrated Traditional Chinese and Western Medicine; Meta Analysis

過敏性咳嗽（Atopic cough，AC）在临床上又被称为变应性咳嗽，为儿科常见的疾病之一。该病最主要的特征表现为刺激性干咳。由于小儿的咳嗽反射敏感性较一般人高，呼吸道炎症因子如嗜酸粒细胞等浸润后出现炎症，从而出现咳嗽。因其临床表现与咳嗽变异性哮喘很相似，故一段时间内将这两种疾病合称为咳嗽变异性哮喘。直至2013年中国医学会儿科分会在《中国儿童慢性咳嗽诊断与指南临床》[1]中明确提出了过敏性咳嗽不是咳嗽变异性哮喘，并且在诊断标准及治疗原则方面加以区别。部分过敏性咳嗽的儿童通常可能伴有过敏性鼻炎，由于该病的特点是咳嗽反复发作、迁延难愈，临床上更加容易被误诊为呼吸道感染性疾病，错误的使用抗生素治疗，收效甚微甚至发展为咳嗽变异性哮喘，威胁儿童的身体健康。临床相关研究运用中西医结合治疗小儿过敏性咳嗽取得良好成效。……