百合大枣粥改善失眠的网络营养药理学研究

赵安达 张海峰 唐雯 孙娟 刘希鹏 刘喆

【摘要】目的：探讨百合大枣粥改善失眠的作用机制。方法：通过网络药理学方法，研究百合、大枣中活性组分的营养药理作用。利用TCMSP数据库筛选百合、大枣的活性组分和作用靶点，随后利用DrugBank数据库筛选出失眠相关的作用靶点。将百合、大枣活性成分对应的靶点与失眠相关靶点取交集，并对交集的靶点进行GO和KEGG富集分析。结果：共筛选到有效活性成分百合7种，大枣29种；作用靶点百合46个，大枣204个，其中与失眠相关的作用靶点有38个，它们主要通过胆碱能系统、5-羟色胺、GABA、cAMP等信号通路改善失眠。结论：百合大枣粥改善失眠存在多组分、多靶点和多途径作用，本研究为进一步研究失眠提供了科学基础。

【关键词】百合；大枣；失眠；网络营养药理学

【中图分类号】R256.23 【文献标识码】A 【文章编号】2096-5249（2021）04-0011-03

Mechanism of Lilii bulbus-Jujubae fructus porridge on improving insomnia based on network nutritional pharmacology

Zhao anda，Zhang Haifeng，Tang Wen，Sun Juan，Liu Xipeng，Liu Zhe

Department of Clinical Nutrition，Shanghai Ninth People’s Hospital，Shanghai Jiao Tong University School of Medicine，Shangha 200011，China

【Abstract】Objective：To explore the mechanism of Lilii bulbus-Jujubae fructus porridge on improving insomnia. Methods：Using network pharmacology method the nutritional and pharmacological effects of L. bulbus and J. fructus were studied. Active ingredients and targets of L. bulbus and J. fructus were screened out through TCMSP database. Potential targets related to insomnia were screened out through DrugBank. The intersections of the above targets were taken for KEGG and GO enrichment analysis.Results：Totally， 7 and 29 effective active ingredients were found in L. bulbus and J. fructus， respective. 46 and 204 targets were screened out from L. bulbus and J. fructus， respective， in which there were 38 overlapping targets with insomnia. These targets improve insomnia mainly through cholinergic system， 5-hydroxytryptamine， GABA， cAMP signaling pathways. Conclusion：L. bulbus and J. fructus possess multi- ingredients，multi-targets and multi-pathways to improve insomnia. The present study provides a scientific basis for further research on insomnia.

【Key words】Lilii bulbus； Jujubae fructus； insomnia； network nutritional pharmacology

現代社会生活节奏加快，失眠是一种常见的临床疾病，据估计在中国约有15 %人存在失眠[1]。持续的失眠不仅会使身体疲惫，无法恢复精力，还会损害认知功能，增加焦虑、抑郁的风险，严重影响生活质量[2-7]。目前，现代医学治疗失眠以药物为主，尽管部分药物见效快，但同时存在依赖性、不耐受和停药后复发等问题[8]。因此，有疗效而无依赖、易耐受、无复发等问题的治疗方法值得进一步研究。中医药膳是含有传统中药、具有保健、防治疾病作用的膳食，其隐药于食，兼顾安全与疗效等[9]。百合大枣粥是一种常用于改善失眠的药膳，其核心成分百合与大枣皆为药食同源，在传统医学中前者具有养阴润肺，清心安神功效，后者则有补中益气，养血安神作用。……