FeNO、IgE、FEV1%及炎性因子在支气管哮喘患者中的表达水平及价值

朱时宝

[摘要]目的探析呼出氣一氧化氮（FeNO）、免疫球蛋白 E（IgE）、第1秒用力呼气量占预计值百分比（FEV1%）及炎性因子在支气管哮喘患者中的表达情况。方法选取连云港市赣榆区人民医院2018年2月至2020年7 月收治的60例支气管哮喘患者为研究对象进行回顾性分析，其中急性发作期患者30例设为急性组，缓解期患者30例设为缓解组，同时选取健康体检者30例为参照组，检测比较各组FeNO、IgE、FEV 1%、炎性因子水平。结果急性组、缓解组FeNO、IgE水平显著高于参照组，急性组 FEV 1%水平显著低于参照组（ P <0.05）;缓解组FeNO、IgE水平显著低于急性组， FEV1%水平显著高于急性组（ P <0.05）;参照组与缓解组 FEV1%水平差异无统计学意义（ P >0.05）。急性组、缓解组 IL-4、IL-6显著高于参照组，急性组显著高于缓解组（ P <0.05）。结论支气管哮喘患者FeNO、IgE、炎性因子水平明显升高，可作为临床诊治的参考依据。而 FEV1%只在支气管哮喘急性发作期变化明显，不一定能反映气道的炎症程度。

[关键词]支气管哮喘;呼出气一氧化氮;免疫球蛋白 E;第1秒用力呼气量占预计值百分比

[中图分类号] R562.2+5  [文献标识码] A   [文章编号]2095-0616（2021）24-0218-03

Expression level and value of FeNO， IgE， FEV1% and inflammatory factors in patients with bronchial asthma

ZHU  Shibao

Department of Respiratory Medicine， Ganyu District People's Hospital of Lianyungang City， Jiangsu， Lianyungang 222100， China

[Abstract] Objective To explore the percentage of expiratory nitric oxide （FeNO）， immunoglobulin E （IgE）， and forced expiratory volume in the first second to the predicted value（FEV1%） and the expression of inflammatory factors in patients with bronchial asthma. Methods A retrospective analysis of 60 patients with bronchial asthma admitted to Ganyu District People's Hospital of Lianyungang City from February 2018 to July 2020 were selected as the research objects. Among them， 30 patients in the acute attack stage were set as the acute group， and 30 patients in the remission stage were set as the remission group. At the same time， 30 healthy subjects were selected as the reference group， and the levels of FeNO， IgE， FEV1%， and inflammatory factors in each group were tested and compared. Results The levels of FeNO and IgE in the acute group and the remission group were significantly higher than those of the reference group . The FEV 1% level of the acute group was significantly lower than that of the reference group （P <0.05）; The FeNO and IgE levels of the remission group were significantly lower than those of the acute group， and the FEV1% level was significantly higher than that of the acute group （P <0.05）; there was no significant difference in the FEV1% level between the reference group and the remission group （P >0.05）. The IL-4 and IL-6 of the acute group and the remission group were significantly higher than the reference group， and the acute group was significantly higher than the remission group （P <0.05）. Conclusion The levels of FeNO， IgE， and inflammatory factors in patients with bronchial asthma are significantly increased， which can be used as a reference for clinical diagnosis and treatment. However， FEV1% only changes significantly during the acute exacerbation of bronchial asthma， and may not necessarily reflect the degree of airway inflammation.

[Key words] Bronchial asthma; Exhaled nitric oxide; Immunoglobulin E; The number of forced exhalations in the first second is a percentage of the estimated value

支气管哮喘是一种气道慢性炎症病变，气道上皮细胞、嗜酸性粒细胞、中性粒细胞、淋巴细胞、肥大细胞均参与其中[1]。在临床中，支气管镜下支气管灌洗液与支气管内膜活检是评定气道炎症的金标准，但具有一定的创伤性，加之费用较高，临床应用局限性较大[2]。所以，近些年来，哮喘气道炎症检测方法成为了临床研究的重要课题。临床研究发现，内源性一氧化氮（nitric oxide， NO）与哮喘气道炎症息息相关，且呼出气一氧化氮（FeNO）与气道高反应性、气道炎症有着显著的相关性，可体现气道炎症状态，成为了评价哮喘炎症的标志物，具有操作简单、快速、安全的特点。基于此，本研究以连云港市赣榆区人民医院（我院）2018年2月至2020年7月收治的60例支气管哮喘患者为研究对象，探讨FeNO、免疫球蛋白 E（IgE）、第1秒用力呼气量占预计值百分比（FEV1%）、炎性因子表达水平。……