基于数据挖掘探究治疗动脉粥样硬化的组方规律

莫琼 吴悠 韦迪 郝二伟 覃文慧

摘要 目的：分析中国期刊全文数据库（CNKI）治疗动脉粥样硬化专利及用药规律，为中医经验的传承与发展奠定基础。方法：通过检索《中国知网专利数据库》关于治疗动脉粥样硬化的中药专利，利用Excel 2010和中医传承辅助系统（V2.50）对申请专利年份、地区、药物及其类别、关联度进行系统处理，并对结果进行有效分析。结果：共收集到370个专利，涉及药物780味，累计引用3 809频次;频次排名前5位的药物类别为补虚药（683）、活血化瘀药（610）、清热药（221）、解表药（220）、利水渗湿药（169）;使用频次（f）≥30的中药有23味，频次排名前5位的药物为丹参、山楂、黄芪、川芎、三七;药性以温热居多，5味主要以甘、苦、辛为主，归经以归肝、脾、心经居多;频次≥25的药物组合有21个，包含15味药物，所得新处方12个。结论：我国动脉粥样硬化防治状况十分严峻，但防治动脉粥样硬化中药的专利数量近几年有下降趋势，需要加强对动脉粥样硬化疾病的重视。对治疗动脉粥样硬化中药专利进行系统分析，得到候选新方12個，为临床治疗动脉粥样硬化用药提供参考。

关键词 动脉粥样硬化;数据分析;中医传承辅助系统;中药

Research on the Prescription Rules for the Treatment of Atherosclerosis Based on Data Mining

MO Qiong1，2，3，WU You1，2，3，WEI Di1，2，3，HAO Erwei1，2，QIN Wenhui1，2，3

（1 Guangxi Key Laboratory for Pharmacodynamics Research of Traditional Chinese Medicine Guangxi University of Chinese Medicine，Nanning 530001，China; 2 Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues，Nanning 530200，China; 3 Faculty of Pharmacy，Guangxi University of Chinese Medicine，Nanning 530200，China）

Abstract Objective：To use the Traditional Chinese Medicine Inheritance Support System（TCMISS）（V2.5），the patents of atherosclerosis in the China National Knowledge Infrastructure（CNKI） are analyzed to lay a foundation for the inheritance and development of the experience of traditional Chinese medicine.Methods：In this paper，the author searched anti-atherosclerosis patents on traditional Chinese medicine in the CNKI.This article uses Excel 2010 and the TCMISS（V2.50） to systematically process by the way of the year，region，medicine，category and degree of relevance of the patents application and analyze the results effectively.Results：In this paper，a total of 370 patents involving 780 flavors of drugs were collected，with a cumulative frequency of 3809.The top five drug categories are tonic deficiency drugs（683），activating blood circulation and removing blood stasis drugs（610），heat-clearing drugs（221），relieving superficies medicines（220） and diuretic medicine（169）.Chinese medicines with frequency（f）≥ 30 have 23 flavors，which of The top five medicines are Salvia miltiorrhiza Bge.，Crataegus pinnatifida Bunge，stragalus membranaceus（Fisch.） Bunge.，ligusticum chuanxiong hort.，Panax notoginseng..The medicinal properties are mostly warm.The frequency of five flavors is frequent the order is sweet，bitter，and spicy and most of channel tropism are liver，spleen and heart.Conclusion：In China，the condition of atherosclerosis is very serious，but the number of patents for atherosclerosis in traditional Chinese medicines has been declining in recent years.We need to pay more attention to atherosclerosis.The author systematically analyzed the patents of traditional Chinese medicines for the treatment of atherosclerosis and obtained 12 new prescriptions，which provides references for the clinical treatment of atherosclerosis.

Keywords Atherosclerosis; Logical analysis of data; Inheritance Auxiliary System of Traditional Chinese medicine; Traditional Chinese medicine

中图分类号：R282;R541文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.16.021

动脉粥样硬化（Atherosclerosis，AS）是指在血管壁内膜和内膜下存在脂质沉积，伴有中层平滑肌细胞向内膜迁移、增殖，使内膜增厚而形成粥样病灶或纤维脂质斑块病灶的一种慢性疾病，其为缺血性脑血管疾病中风、冠心病等心血管疾病的病理基础[1-3]。根据《中国心血管病报告2014》的统计结果，目前估计全国有心血管病患者2.9亿，AS是心血管疾病常见病症之一。……