中药复方及微粉化黄体酮改善先兆流产患者临床结局研究综述

张多加 陈京京 吴效科

摘要 目前，临床上针对先兆流产的治疗药物以地屈孕酮、黄体酮以及孕激素为主，其中黄体酮作为纯天然的激素类药物治疗先兆流产的优势近年来日益凸显，已有成为治疗先兆流产首选药物的趋势。近年来，随着中医药治疗在临床上应用的日益广泛，中药复方治疗先兆流产作为一种可行方式开始受到广泛关注。通过对中药复方及微粉化黄体酮改善先兆流产患者临床结局相关研究进展的总结，旨在为先兆流产患者的临床治疗提供参考。

关键词 先兆流产;中药复方;微粉化黄体酮;激素;临床结局;综述

Research Summary of Traditional Chinese Medicine Compound and Micronized Progesterone to Improve Clinical Outcomes of Patients with Threatened Abortion

ZHANG Duojia，CHEN Jingjing，WU Xiaoke

（The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine，Harbin 150040，China）

Abstract At present，clinically，the main treatment drugs for patients with threatened abortion are dichroprenone，progesterone，and progesterone，in which progesterone treatment of threatened abortion advantages in recent years are increasingly prominent，which has become the treatment of threatened abortion drug of choice trend.In recent years，with the increasingly extensive clinical application of traditional Chinese medicine（TCM），TCM compound therapy for threatened abortion as a feasible method has begun to receive extensive attention.Through the summary of the research progress related to the improvement of the clinical outcome of threatened abortion patients with Chinese medicine compound and micronized progesterone，it aims to provide reference for the clinical treatment of threatened abortion patients.

Keywords Threatened abortion; Chinese herbal compound; Micronized progesterone; Hormone; Clinical outcome; Review

中图分类号：R271.42;R271.9文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.16.025

先兆流产属于临床上较为常见的妊娠并发症之一，患者主要临床表现包括阴道流血、伴或不伴腹痛、宫颈口闭合以及宫腔内胎儿可见等。先兆流产发病率约为20%，患者发生流产的概率达50%[1]。近年来，随着相关研究的不断深入，越来越多的学者发现先兆流产的发病因素可能包括染色体、基因、解剖结构、免疫学、激素水平、感染及心理因素等，且父母年龄过大以及母亲患有全身性疾病亦会引发该病[1]。由于该病常发生于妊娠早期，与健康成年孕妇比较，先兆流产患者发生产前出血、胎膜早破、早产和胎儿宫内发育迟缓的风险更高，且更易发生焦虑不安、精神不佳、睡眠障碍、情绪暴躁等多种心理障碍性疾病，不仅会对患者的身心健康造成严重影响，甚至会影响患者家庭的和睦[2]。因此，寻找一种有效的先兆流产治疗手段显得尤为重要，目前已成为妇产科医生共同关注的热点。……