痰热清联合干扰素雾化治疗手足口病小儿疗效及对心肌酶谱、血清细胞因子水平的影响

庞军 王通敏

【摘要】目的：观察痰热清+干扰素雾化治疗方法，应用于手足口病患儿中的效果。方法：我院儿科2020年1月～2020年12月区间内收治的92例手足口病患儿，选用随机抽签方法分为了实验组46例、参照组46例。参照组通过对症+干扰素方案治疗，实验组在参照组之上配合痰热清治疗，予以对比两组的临床效果。结果：①实验组的治疗效果、参照组的治疗效果比较，P<0.05。②实验组的心肌酶谱情况、参照组的心肌酶谱情况比较，P<0.05。③实验组的血清细胞因子水平、参照组的血清细胞因子水平比较，P<0.05。结论：手足口病患儿治疗中痰热清+干扰素雾化方案的运用，能够保证临床疗效，同时使得患儿心肌酶谱、血清细胞因子水平下降，故此值得在该病患儿的治疗中加以应用和推广。

【关键词】痰热清;干扰素;雾化治疗;手足口;心肌酶谱;血清细胞因子

【Abstract】 Objective： To observe the effect of Tanreqing + interferon atomization therapy on children with hand， foot and mouth disease. Methods： 92 children with hand， foot and mouth disease treated in pediatrics of our hospital from January 2020 to December 2020 were randomly divided into experimental group and reference group. The reference group was treated with symptomatic + interferon regimen， and the experimental group was treated with Tanreqing on top of the reference group. The clinical effects of the two groups were compared. Results： ① the therapeutic effect of the experimental group was compared with that of the reference group （P < 0.05）. ② The myocardial zymogram of the experimental group was compared with that of the reference group （P < 0.05）. ③ The level of serum cytokines in the experimental group was compared with that in the reference group （P < 0.05）. Conclusion： the application of Tanreqing + interferon atomization scheme in the treatment of children with hand， foot and mouth disease can ensure the clinical efficacy and reduce the levels of myocardial enzymes and serum cytokines. Therefore， it is worthy to be applied and popularized in the treatment of children with hand， foot and mouth disease.

【Key words】 Tanreqing; Interferon; Atomization therapy; Hand， foot and mouth; Myocardial zymogram; Serum cytokines

手足口病，作為肠道病毒感染所引发的急性传染性疾病，病情严重的患儿还会伴心肌炎、脑脊髓炎及肺水肿等并发症状况，直接威胁到患儿的生命健康。临床方面多会采用抗病毒、对症方法治疗，干扰素作为广谱抗病毒活性糖蛋白，在对病毒复制抑制方面的效果理想，而且能够很好的调节患儿免疫功能。痰热清为中药注射剂，化痰和清热解毒的效果较佳。针对于此，本文将我院儿科2020年1月～2020年12月时间段，抽取的92例手足口病患儿作为评价对象，重点评判对症+干扰素方案、痰热清+干扰素方案的应用，对提高患儿临床疗效、降低心肌酶谱和血清细胞因子水平的作用。……