【摘要】目的:比较儿童细菌性肺炎降钙素原与血培养阳性率差异,探讨血清降钙素原检测价值。方法:选择2019年1月至2020年6月诊治儿童细菌性肺炎124例,进行血清降钙素原及血液细菌培养检测;观察指标包括血清降钙素原及血培养阳性率、病情程度不同患儿血清降钙素原水平、血培养阳性中革兰阴性菌与阳性菌血清降钙素原水平。结果:124例患儿血清降钙素原水平(1.25±0.38)ug/L,血清降钙素原(+)67.74%;血培养(+)33.87%,血清降钙素原(+)高于血培养(P<0.05)。重症肺炎患儿血清降钙素原水平(4.36±0.77)ug/L高于普通肺炎患儿的(0.98±0.21)ug/L(P<0.05)。革兰阴性菌患儿血清降钙素原水平(3.17±0.75)ug/L高于革兰阳性菌患儿的(1.24±0.41)ug/L(P<0.05)。结论:儿童细菌性肺炎血清降钙素原(+)高于血培养(+), 血清降钙素原检测对儿童细菌性肺炎早期诊断及病情判断有指导意义。
【关键词】细菌性肺炎;儿童;血清降钙素原;血培养;
[中图分类号]R446.1 [文献标识码]A [文章编号]2096-5249(2021)09-0154-02
Comparison of serum procalcitonin and blood culture in diagnosis of children bacterial pneumonia
LI Xiao-hong(Laboratory of the first peoples Hospital of Taicang City, Taicang Jiangsu 215400, China)
[Abstract] Objective: To compare the positive rates of procalcitonin and blood culture in children with bacterial pneumonia, explore the value of serum procalcitonin detection. Methods: 124 cases of children with bacterial pneumonia from January 2019 to June 2020 were selected for detection of serum procalcitonin and blood bacterial culture; the observation indexes included serum procalcitonin and positive rate of blood culture, serum procalcitonin level of children with different disease degree, and serum procalcitonin levels of Gram-negative bacteria and positive bacteria in blood culture positive. Results: Serum procalcitonin level (1.25±0.38) UG / L in 124 cases. Serum procalcitonin (+) was 67.74%, Blood culture (+) was 33.87%. Serum procalcitonin (+)higher than blood culture(P<0.05). severe pneumonia serum procalcitonin level (4.36±0.77) UG / L was higher than children with common pneumonia (0.98±0.21) UG/ L(P<0.05). The serum procalcitonin level in children with gram-negative bacteria (3.17±0.75) UG / l was higher than that in children with Gram-positive bacteria (1.24±0.41) UG / L (P<0.05). Conclusion: bacterial pneumonia serum procalcitonin (+)was higher blood culture (+), and the serum procalcitonin level in severe and gram-negative bacterial pneumonia was higher than that in common and gram-positive bacterial pneumonia, detection serum procalcitonin has guiding significance for early diagnosis and disease judgment of bacterial pneumonia.
[Key words] Children; Bacterial pneumonia; Serum procalcitonin; Blood culture
兒童肺炎是儿科常见的疾病,临床上主要是通过血培养或痰培养等微生物检测对儿童细菌性肺炎进行诊断,但微生物检测诊断耗费长阳性率也比较低,因此,寻找一种更有诊断价值的实验室指标对诊断儿童细菌性肺炎具有重要意义[1, 2]。本文2019年1月至2020年6月比较儿童细菌性肺炎中血培养及血清降钙素原检查结果的差异,为临床诊断提供参考,报道如下。
1 资料与方法
1.1一般资料 江苏省太仓市第一人民医院2019年1月至2020年6月诊治儿童细菌性肺炎124例,普通肺炎110例、重症肺炎14例;男64例、女60例,患儿年龄1个月~14岁,平均年龄(5.80±1.33)岁。排除无法正常交流或存在精神疾病;正参与其他研究者。
1.2检测方法 ①血清降钙素原检查:常规消毒采集研究对象静脉血3 mL于有分离胶的真空管,离心留取血清应用cobase 601分析仪检测,血清降钙素原>0.5ng/mL,结果为阳性。②血液细菌培养检测:血液细菌培养检测:常规消毒采集研究对象静脉血于含树脂儿童瓶,儿童瓶采集量为1.0~3.0 mL;利……