多西他赛、顺铂联合三维适行放疗治疗局部晚期非小细胞肺癌

史建军 邵汛帆 邓敬锋 周明

[摘要] 目的：探讨多西他赛、顺铂联合三维适行放疗治疗局部晚期非小细胞肺癌的疗效。方法：将入组43例非小细胞肺癌患者随机分为观察组（22例）和对照组（21例）。对照组采用序贯疗法，多西他赛+顺铂，3周为1个周期，共化疗4个周期后开始放疗；放射治疗采用三维适行放疗。观察组采用同期放化疗，即化学治疗开始时同步进行放射治疗，具体化疗药物及剂量、放疗方法同对照组。结果：两组患者临床疗效比较，观察组总有效率为86.36%，对照组总有效率为57.14%，两组总有效率比较差异有统计学意义（P＜0.05）。两组患者毒性反应、早期放射反应比较差异均无统计学意义（P＞0.05）。结论：多西他赛、顺铂联合三维适行放疗治疗局部晚期非小细胞肺癌疗效确切。

[关键词] 非小细胞肺癌；三维适行放疗；多西他赛；顺铂

[中图分类号] R734.2 [文献标识码]A[文章编号]1673-7210（2011）11（c）-072-03

Treatment on locally advanced non-small cell lung cancer by Docetaxel, Cis-platinum combined with three-dimensional conformal radiotherapy

SHI Jianjun1, SHAO Xunfan1, DENG Jingfeng1, ZHOU Ming2

1.Department of Radiotherapy, Guangzhou Medical University Cancer Institute and Hospital, Guangdong Province, Guangzhou 510095, China; 2.Department of Thoracic Surgery, Guangzhou Medical University Cancer Institute and Hospital, Guangdong Province, Guangzhou 510095, China

[Abstract] Objective: To discuss the treatment effect on local advanced by Docetaxel non-small cell lung cancer, Cis-platinum combined with three-dimensional conformal radiotherapy. Methods: 43 cases of patients with enrolled in groups were randomly divided into observation group (22 cases) and control group (21 cases). The control group was adopted sequence therapy by Docetaxel and Cis-platinumt, three weeks as a cycle; after chemotherapy for four cycles, radiotherapy began to be used, three-dimensional conformal radiotherapy was adopted in it. Concurrent chemotherapy was adopted in the observation group that chemotherapy and radiotherapy began simultaneously; its specific chemotherapeutic medicine and dosage and its radiotherapy were the same as those of the contrast group. Results: Comparing the clinical treatment effects of patients in two groups, the total effective rate of the observation group was 86.36%; the total effective rate of the control group was 57.14%; the difference was statistically significant (P＜0.05); and there was no obvious difference of toxicity, side effect and early radioreaction between the two groups (P＞0.05). Conclusion: The combination of Docetaxel, Cis-platinum combined with three-dimensional conformal radiotherapy has an exact treatment effect on local advanced non-small cell lung cancer.

[Key words] Non-small cell lung cancer; Three-dimensional conformal radiotherapy; Docetaxel; Cis-platinum

肺癌是临床常见的恶性肿瘤之一，严重威胁着人们的健康和生命。肺癌的病死率在常见恶性肿瘤中居首位，流行病学调查显示，全球大约每年有130万人死于肺癌[1]。非小细胞肺癌（non-small cell lung carcinoma，NSCLC）的发病率约占肺癌总数的80%，且其发病率呈逐年上升趋势[2]。放射治疗作为一种有效的局部治疗手段，在肺癌患者中的临床应用越来越广泛。但NSCLC明确诊断时有30%～40%属于不能切除的局部晚期肺癌，单纯的化学或放射治疗效果均不理想[3]。我院于2008年2月～2010年7月采用多西他赛、顺铂联合三维适行放疗治疗局部晚期非小细胞肺癌的前瞻性研究，取得了满意的效果。……