白细胞介素-11雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的疗效观察

杨乐伟  孙玉勤  陈嘉洛  杨光伟

[摘要] 目的 探讨白细胞介素-11（IL-11）雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的临床疗效，为鼻咽癌同期放化疗导致口腔黏膜炎的治疗提供新方法。 方法 选取2010年4月～2013年6月间于我院肿瘤科住院治疗的初诊为鼻咽癌的患者84例，于放疗后2周即药物雾化吸入前，及放疗第3～7周观察口腔黏膜反应变化情况；于放疗结束后1周，观察口腔黏膜反应愈合情况，对比分析IL-11雾化吸入对鼻咽癌同期放化疗导致口腔黏膜炎的治疗效果。 结果 两组患者放疗后第2周均出现口腔黏膜反应，但观察组患者的口腔黏膜反应分级与对照组相比无显著变化，但随着放射治疗的持续以及放射剂量的增加，观察组患者的口腔黏膜反应分级以Ⅰ～Ⅱ度黏膜反应为主，而对照组患者的口腔黏膜反应分级以Ⅱ～Ⅲ度黏膜反应为主，两组患者组间比较发现，观察组患者的口腔黏膜反应程度较对照组显著增加（P＜0.05）；放疗结束１周后，观察组对于口腔黏膜炎治疗的总有效率为90.5%，与对照组相比显著升高（x2=27.064，P=0.000）。 结论 IL-11雾化吸入能够有效减轻鼻咽癌同期放化疗导致口腔黏膜反应的程度，对于口腔黏膜炎的治疗具有促进作用。

[关键词] 白细胞介素-11；鼻咽癌；放射治疗；口腔黏膜炎；药物疗法

[中图分类号] R739.63   [文献标识码] A   [文章编号] 2095-0616（2014）08-20-04

Efficacy of interleukin-11 inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma

YANG Lewei  SUN Yuqin  CHEN Jialuo  YANG Guangwei

Department of Cancer Radiation Oncology, Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000,China

[Abstract] Objective To investigate the clinical efficacy of interleukin-11(IL-11) inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma and to provide a new method for the treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma. Methods 84 patients were selected in the oncology of our hospital during April 2010 to June 2013, which were diagnosed with newly nasopharyngeal cancer. The changes of oral mucositis were observed before the drug inhalation and 3-7 weeks after radiotherapy, and the healing of oral mucositis were also observed one week after the end of radiotherapy. And then the clinical efficacies of interleukin-11(IL-11) inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma were analyzed comparatively. Results In the first two weeks, the patients of both two groups existed oral mucositis after radiotherapy, but compared with the control group, oral mucositis classification in the observation group had no change significantly, but with the continued increase in radiation dose and radiation therapy, the degree of the patients in the observation group were mainly gradeⅠ-Ⅱ degree, and those in the control group were mainlyⅡ-Ⅲ degree. Between two groups of patients found the oral mucosa of patients in the observation group compared with the extent of reaction the control group was significantly increased(P＜0.05); 1 week after the end of radiotherapy, the effective rate was 90.5% in the observation group to the total oral mucositis treatment, compared with the control group was significantly higher(x2=27.064,P=0.000). Conclusion IL-11 inhalation can effectively reduce the degree of oral mucositis caused by nasopharyngeal concurrent chemo-radiotherapy, and has a facilitating role for the treatment of oral mucositis.

[Key words] Interleukin-11; Nasopharyngeal carcinoma;Radiation therapy;Oral mucositis;Drug therapy

鼻咽癌是临床常见的头颈部恶性肿瘤，其发病具有显著的地域性特征，在我国华南地区较为流行[1-2]，其病因尚不明确，环境因素、遗传因素、病毒感染等均能诱发鼻咽癌[3]，近年来，其发病率呈逐年上升的趋势，严重威胁着患者的健康。……