纳洛酮治疗脑血栓的临床效果观察

刘启军

[摘要] 目的 探讨纳洛酮治疗脑血栓的临床效果。 方法 选取本院2012年1月～2014年1月收治的脑血栓患者60例，将其随机分为观察组和对照组，观察组在常规治疗的基础上加用纳洛酮治疗，对照组在常规治疗的基础上加用复方丹参治疗，比较两组的治疗效果。 结果 观察组治疗总有效率为93.3%，高于对照组的76.7%；平均起效时间为（7.65±2.43） d，短于对照组的（10.18±2.65） d；治疗后的NIHSS评分为（6.15±1.26）分，低于对照组的（12.48±2.88）分；两组上述指标差异有统计学意义（P<0.05）。两组治疗期间均未见明显不良反应。 结论 纳洛酮治疗脑血栓效果显著，对快速改善症状、提高治疗效果、改善预后具有重要作用。

[关键词] 脑血栓；纳洛酮；临床疗效

[中图分类号] R743[文献标识码] A[文章编号] 1674-4721（2014）06（c）-0083-03

Clinical effect observation of naloxone in treatment of cerebral thrombosis

LIU Qi-jun

Department of Medical Insurance,Ganzhou City Hospital of Jiangxi Province,Ganzhou 341000,China

[Abstract] Objective To explore the clinical efficacy of naloxone in the treatment of cerebral thrombosis. Methods 60 cases of patients with cerebral thrombosis admitted and treated in our hospital from January 2012 to January 2014 were selected and randomly divided into observation group and control group.Naloxone was added to the observation group on the basis of conventional treatment and compound salvia miltiorrhiza was added to the control group on the basis of conventional treatment.The therapeutic effects were compared between the two groups. Results In the observation group,the total effective rate was 93.3%,higher than 76.7% of the control group;average onset time was (7.65±2.43) d,shorter than (10.18±2.65) d of the control group;and post-treatment NIHSS score was 6.15±1.26,lower than 12.48±2.88 of the control group;with significant difference (P<0.05).There was no significant adverse reaction in the two groups during treatment. Conclusion Naloxone has significant efficacy for treatment of cerebral thrombosis and plays an important role in improving symptoms,therapeutic effects and prognosis.

[Key words] Cerebral thrombosis;Naloxone;Clinical efficacy

脑血栓即脑栓塞，是临床最常见心脑血管疾病之一，主要是指由于异常的固态、液体、气态物体沿血循环进入脑动脉系统，引起动脉管腔闭塞，从而导致该动脉供血区局部脑组织坏死，临床主要表现为神经功能缺损症状，如偏瘫、失语、麻木等。对于该病的治疗关键在于改善脑循环，减轻缺血缺氧所致的脑损害，从而快速改善患者临床症状。纳洛酮是临床最常用的阿片类受体拮抗剂，本文探讨纳洛酮治疗脑血栓的临床效果。

1 资料与方法

1.1 一般资料

选取本院在2012年1月～2014年1月收治的脑血栓患者60例，均符合2004第四届全国临床心脑血管疾病学术会议通过的相关诊断标准，所有患者均为首次发病，并均经病因、临床表现及实验室和影像学等检查明确诊断。将所有患者随机分为观察组和对照组，各30例，观察组中男性20例，女性10例，年龄48~82岁，平均（72.3±5.6）岁，CT显示：脑梗死16例，腔隙性梗死9例，多发性脑梗死5例；……