不同粒径三黄粉粉体学性质及体外溶出度比较

范凌云等

摘要：目的 考察三黄细粉与三黄微粉的粉体学性质及体外溶出度，为其直接使用和作为中药制剂原料应用提供依据。方法 对普通三黄细粉和三黄微粉的粒径分布、松密度与振实密度、休止角、吸湿性等粉体学性质进行考察和评价，采用紫外分光光度法测定二者体外溶出度并进行比较。结果 三黄细粉及微粉的流动性均较差，随着粒径减小，微粉的吸湿性增强；三黄微粉较细粉的体外溶出更加迅速而充分。结论 三黄微粉与三黄细粉的粉体学性质差异明显。三黄微粉的吸湿性更强，流动性欠佳，但溶出更迅速且充分，直接使用和作为中药制剂原料应用时需酌情处理。

关键词：三黄粉；超微粉碎；粉体学性质；吸湿性；体外溶出度

DOI：10.3969/j.issn.1005-5304.2015.09.025

中图分类号：R283.6 文献标识码：A 文章编号：1005-5304（2015）09-0091-04

Comparison of Micromeritics Properties and External Dissolution Rates of Sanhuang Powder with Different Particle Sizes FAN Ling-yun， WANG Zhen-heng， YU Yan， GAO Jian-de， WEI Shu-chang （Gansu University of Chinese Medicine， Lanzhou 730000， China）

Abstract：Objective To compare the micromeritics properties and external dissolution rates of Sanhuang Powder in different particle sizes；To provide references for its direct use and application as raw materials for TCM preparation. Methods Particle size， bulk density， tap density， angle of repose， and hygroscopicity of Sanhuang micro-powder and common powder were investigated and evaluated. External dissolution rates of Sanhuang micro-powder and common powder were detected by ultraviolet spectrophotometry. Results The flowability of both Sanhuang micro-powder and common powder were not very well. With the sizes decreasing， the hygroscopicity of micro-powder became stronger. The external dissolution of Sanhuang micro-powder was more sufficient and much more quickly than common powder. Conclusion Properties of Sanhuang micro-powder and common powder are obviously different. Sanhuang micro-powder has stronger hygroscopicity and worse flowability compared with common powder. However， external dissolution of Sanhuang micro-powder is more sufficient and much more quickly than common powder. When Sanhuang micro-powder is used directly and used as raw materials for TCM preparation， much more discretion should be considered.

Key words：Sanhuang Powder；superfine grinding；micromeritics property；hygroscopicity；external dissolution rate

三黄指黄芩、黄连、黄柏， 性味苦寒，为临床常用药对，合用清热燥湿、泻火解毒，治疗湿热内盛、热毒炽盛之证。三黄粉为三药的等比例粉碎混合物，临床可作为三黄胶囊、三黄片、三黄栓等中成药的原料，应用广泛。

超微粉碎可使药材破壁，有效成分溶出增加，其溶解性、分散性、化學反应活性更好，生物利用度更

通讯作者：余琰，E-mail：lzdxyuyan@126.com

高[1]。但微粉的吸湿性增大，流动性变差。因此，本研究对三黄药材的普通细粉和超微粉体的粉体学性质和体外溶出度进行比较和评价，为三黄粉的直接使用和作为中药制剂原料应用提供依据。

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