肾细胞癌中鸟嘌呤核苷酸解离抑制因子2的表达及意义

赵波　李颖毅

[摘 要] 目的：探讨肾细胞癌组织中鸟嘌呤核苷酸解离抑制因子2（RhoGDI2）的表达及其与临床病理因素关系。方法：选择2010年1月至2014年8月期间60例肾细胞癌患者为研究对象；检测癌及癌旁组织RhoGDI2表达，分析RhoGDI2的表达与肾细胞癌临床病理关系。结果：肾细胞癌组织中RhoGDI2的表达水平高于癌旁组织，肾细胞癌组织中RhoGDI2表达的阳性率（70.0%）显著高于癌旁组织（38.3%），差异有统计学意义（χ2=12.1175，P=0.0005）；肾细胞癌组织中RhoGDI2的表达与病理分期、分化程度、淋巴结转移、肿瘤大小有显著相关性（P<0.05）。结论：RhoGDI2在肾细胞癌中呈高表达；肾细胞癌中RhoGDI2的表达参与了肾细胞癌的发病、转移和进展。

[关键词] 肾细胞癌；鸟嘌呤核苷酸解离抑制因子2；病理

中图分类号：R737.11 文献标识码： B 文章编号：2095-5200（2015）05-122-03

[Abstract] Objective： To study expression of guanine nucleotide dissociation inhibitory factor 2 in renal cell carcinoma and the correlation with clinical pathology. Methods： 60 cases of renal cell carcinoma patients were selected as the research object.The expression of RhoGDI2， and the correlation with clinical pathology in renal cell carcinoma were made for statistical analysis. （1）From Jan. 2010 to Aug. 2014， immunohistochemistry was used to assess the expression of RhoGDI2 in 60 pairs of renal cell carcinoma tissues and adjacent pancreatic tissues， and its correlation with clinicopathological features was also analyzed. Results： RhoGDI2 expression level in renal cell carcinoma tissues was higher than the tissue adjacent to carcinoma. Positive rate （70.0%） of RhoGDI2 expression in renal cell carcinoma tissue was significantly higher than tissue adjacent to carcinoma （38.3%）， and the difference was statistically significant （χ2=12.1175，P=0.0005）. RhoGDI2 expression in renal cell carcinoma tissue were significantly correlated with pathological staging， degree of differentiation， lymph node metastasis， tumor size （P<0.05）. Conclusion： RhoGDI2 is highly expressed in renal cell carcinoma； The expression of RhoGDI2 is involved in the pathogenesis of renal cell carcinoma， metastasis and progress in renal cell carcinoma.

[Key words] Renal cell carcinoma； Guanine nucleotide dissociation inhibitory factor 2； Pathology

肾细胞癌由肾实质泌尿小管上皮系统起源，病理类型以透明肾细胞癌、乳头状肾细胞癌、嫌色细胞性肾细胞癌为主。以50～70岁年龄段人群为肾细胞癌高发人群，其发病率仅次于膀胱癌，恶性程度较高，患者预后亦较差[1-2]；肾细胞癌病因尚不明确，流行病学研究数据显示，其发病与遗传、吸烟、肥胖等因素有关，男性发病率明显高于女性[3-4]。鸟嘌呤核苷酸解离抑制因子2（RhoGDI2）为重要肿瘤转移相关基因[5]，在恶性肿瘤中可呈异常表达，在机体肿瘤转移及进展过程中起重要作用[6-7]，但有关RhoGDI2在肾细胞癌组织中表达与肾细胞癌临床病理关系国内较少。本研究通过检测肾细胞癌中RhoGDI2表达，旨在探讨RhoGDI2在肾细胞癌发生、转移和进展中可能作用。

1 资料与方法

1.1 一般资料

选择2010年1月至2014年8月期间被我院收治60例肾细胞癌患者为研究对象，患者年龄42～80岁，平均（57.2±4.16）岁，男38例，女22 例，体重指数为（21.59±3.10 ）kg/m2。……