飞天蜈蚣七不同提取物的药效学研究

杨秦雁　李　博

陕西省中医医院药剂科 (西安 710002)



飞天蜈蚣七不同提取物的药效学研究

杨秦雁李博

陕西省中医医院药剂科 (西安 710002)

目的：研究比较飞天蜈蚣七不同极性部位提取物的抗炎、镇痛、抗疲劳和耐缺氧的活性。方法：分别采用二甲苯所致耳廓肿胀实验、角叉菜胶所致小鼠足肿胀实验、小鼠扭体法、热板法、负重游泳实验和常压耐缺氧实验对其抗炎、镇痛、抗疲劳、和耐缺氧活性进行研究。结果：飞天蜈蚣七提取物乙醇部位、乙酸乙酯部位和正丁醇部位均表现出不同程度的抗炎、镇痛、抗疲劳作用，尤其以正丁醇部位活性最为显著，而其各部位的耐缺氧活性均不高。结论：飞天蜈蚣七不同极性部位提取物均具有抗炎、镇痛、抗疲劳作用，其中正丁醇部位活性最强。

主题词中药制剂实验，动物@飞天蜈蚣

ABSTRACT

Objective: To study the anti-inflammation, analgesia, anti-fatigue and anti-hypoxia activity of the different extracts from Aralia chinensis L.Methods: The pharmacological actions of anti-inflammation and analgesic were observed by xylene-induced ear swelling in mice, carrageenan-induced paw swelling in mice, acetic acid- induced writhing test and the hot-plate test in mice. Meanwhile, the anti-fatigue and anti-hypoxia effects were investigated by the load bearing swimming test and the hypoxia tolerance test respectively. Results: The ethanol extraction, ethyl acetate extraction and n-butanol extraction of Aralia chinensis L. all had anti-inflammation, analgesia and anti-fatigue effects. The n-butanol extraction had the most significant effect.The anti-hypoxia activity of all the different extracts was weak. Conclusion: The different extracts from Aralia chinensis L. all showed the anti-inflammation, analgesia and anti-fatigue effects. And the n-butanol extract had stronger activity.

飞天蜈蚣七为五加科植物楤木的根皮，分布于陕西、河北、山东、浙江、江西等地, 在陕西主要分布于秦岭、巴山各个山区,主治风湿性关节炎、急慢性肝炎、跌打损伤、痈肿等[1-2]。目前已有文献报道飞天蜈蚣七具有抗肝纤维化作用，但其它药理活性有待进一步研究[3-4]。本研究旨在进一步对飞天蜈蚣七不同极性部位提取物进行药理研究，探讨各部位的药理活性差异，筛选飞天蜈蚣七的主要活性部位，为飞天蜈蚣七药材的进一步开发利用提供参考。

1材料1.1动物昆明种小鼠，体重20±2g，雌雄兼用，购于第四军医大学实验动物中心，合格证号为陕动准字第01号。……