曾龙宏++祁妙华++胡晓婧


[摘要]目的 探讨血栓弹力图与常规凝血指标在弥散性血管内凝血(DIC)患者血液制品输注中的指导价值。方法 选取2016年2月~2017年1月我院收治的输注血液制品治疗的DIC患者58例为研究对象,采用计算机抽取住院号法随机分为A组(29例)和B组(29例)。A组采用血栓弹力图指导,B组采用常规凝血指标指导。比较两组患者的血浆、血小板、冷沉淀输注量及疗效。结果 A组24 h血浆、血小板、冷沉淀输注量均少于B组[(1238.4±356.1)ml vs. (1812.5±468.5)ml,(36.2±5.8)U vs. (44.9±7.6)U,(29.6±6.6)U vs.(39.4±5.8)U](P<0.05)。A组患者的治疗效果显著优于B组(89.66% vs. 62.07%)(P<0.05)。 结论 血栓弹力图在DIC患者中指导输注血液制品,相对常规凝血指标具有更好的临床疗效。
[关键词]弥散性血管内凝血;血栓弹力图;血液制品
[中图分类号] R554+.8 [文献标识码] A [文章编号] 1674-4721(2017)06(b)-0024-03
[Abstract]Objective To explore the guidance value of thrombelastogram and routine coagulation index in the infusion of blood products in patients with diffuse intravascular coagulation (DIC).Methods 58 cases with DIC treated in our hospital and treated by infusing the blood products from February 2016 to January 2017 were selected as objects.The patients were randomly divided into group A (29 cases) and group B (29 cases) adopting the computer extraction inpatient number method.Group A was given thrombelastogram guidance,while group B were given the routine coagulation index.Transfusion volume of plasma,platelet,cold precipitation and curative effect was compared between the two groups.Results Transfusion volume of plasma,platelet,cold precipitation in 24 hours in group A were less those of group B [(1238.4±356.1) ml vs. (1812.5±468.5) ml,(36.2±5.8) U vs. (44.9±7.6) U,(29.6±6.6) U vs. (39.4±5.8) U] (P<0.05).The treatment effect of group A was significantly higher than that of group B (89.66% vs. 62.07%) (P<0.05).Conclusion Thrombelastogram in DIC patients to guide the infusion of blood products has a better clinical efficacy compared with the conventional coagulation index.
[Key word]Diffuse intravascular coagulation;Thrombelastogram;Blood products
彌散性血管内凝血(diffuse intravascular coagulation,DIC)为临床中常见危重症,为多种因素引起微循环凝血功能障碍性疾病,由于微循环发生凝血功能障碍,可引起广泛性血栓形成,消耗大量凝血因子,继发激活纤维蛋白溶解,引起广泛性全身出血,具有较高的致死率[1]。临床中针对DIC不同发生阶段,针对性补充血液制品为治疗DIC关键,通常根据凝血指标指导输注血液制品成份、输注量。随着临床研究深入,血栓弹力图实现对凝血功能进行动态观察,在DIC患者血液制品输注方面具有重要指导价值[2],本研究对血栓弹力图和常规凝血指标在DIC患者血液制品输注中指导价值进行研究,报道如下。
1 资料与方法
1.1 一般资料
选取2016年2月~2017年1月我院收治的输注血液制品治疗的DIC患者58例作为研究对象,随机分为A组和B组,各29例。两组患者均有明确致病病因,根据临床症状、体征,结合实验室影像资料,诊断均符合《弥散性血管内凝血诊治指南》[3],明确诊断为DIC;……