艾迪注射液联合化疗方案治疗晚期结直肠癌的效果

吕遐智

[摘要] 目的 探討艾迪注射液联合化疗方案治疗晚期结直肠癌的效果。 方法 回顾性分析安徽医科大学附属六安医院2013年6月～2016年6月收治的70例晚期结直肠癌患者的临床资料，根据治疗方式的不同将患者分为对照组和观察组，每组各35例。对照组采用奥沙利铂联合卡培他滨常规化疗，观察组在对照组治疗的基础上给予艾迪注射液。比较两组患者的临床疗效，治疗前后采用卡氏评分（KPS）评估患者的生活质量，观察治疗后患者生活质量的改善程度，比较两组患者不良反应的发生情况。 结果 观察组的有效率高于对照组（71.43%比60.00%），差异有统计学意义（P < 0.05）。治疗后观察组KPS评分的改善情况明显优于对照组，差异有统计学意义（P < 0.05）。观察组白细胞下降程度明显低于对照组（P < 0.05），血小板下降、胃肠道反应、神经毒性的严重程度也轻于对照组，但组间差异无统计学意义（P > 0.05）。 结论 艾迪注射液联合化疗方案治疗晚期结直肠癌的效果明显优于单纯化疗，且不良反应少，明显改善了患者的生活质量，值得临床推广应用。

[关键词] 艾迪注射液；晚期结直肠癌；临床疗效；生活质量

[中图分类号] R735.35；R735.37 [文献标识码] A [文章编号] 1673-7210（2017）06（b）-0146-04

Effect of Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer

LYU Xiazhi

Ward One， Department of Medical Oncology， Lu'an Hospital Affiliated to Anhui Medical University， Anhui Province， Lu'an 237000， China

[Abstract] Objective To explore the effect of the Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer. Methods From June 2013 to June 2016， the clinical data of 70 patients with advanced colorectal cancer treated in Lu'an Hospital Affiliated to Anhui Medical University were retrospectively analyzed， patients were divided into control group and observation group according to the different methods of treatment， each group of 35 cases. The control group was treated by the standard chemotherapy of Oxaliplatin combined with Capecitabine， while the observation group was treated by Aidi Injection on the basis of the treatment of control group. The clinical efficacy of the two groups was compared； the quality of life was assessed before and after treatment by Karnofsky performance status （KPS） score， the improvement of quality of life after treatment was observed； the occurrence of adverse reactions of the two groups was compared. Results The effective rate of the observation group was higher than that of the control group （71.43% vs 60.00%）， the difference was statistically significant （P < 0.05）. After treatment， the improvement of KPS score in observation group was better than that of the control group， the difference was statistically significant （P < 0.05）. The degree of white blood cells decline of the observation group was obviously lower than that of the control group （P < 0.05）； the severity of platelet decline， gastrointestinal reaction， neurotoxicity were lighter than those of the control group， but there were no statistically significant differences between the two groups （P > 0.05）. Conclusion The effect of Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer is significantly better than that of the pure chemotherapy， with less adverse reactions， which can obviously improve the quality of life， and it is worthy of clinical popularization and application.

[Key words] Aidi Injection； Advanced colorectal cancer； Clinical curative effect； Quality of life

结直肠癌是世界上最为常见的恶性肿瘤之一，尤其在我国，随着我国人口的老年化，结直肠癌的发病率呈逐年上升的趋势。结直肠癌患者早期症状不明显，早期诊断极为困难，明确诊断时早已错过了手术时机[1]。目前临床上以化疗为晚期结直肠癌的主要治疗方法，而以化疗为主的综合治疗可明显延长患者的生存期，但是化疗药物会对患者产生极大的毒副作用，从而降低患者的生存质量，甚至危及生命。为了保证患者的治疗效果和生活质量，联合其他药物辅助治疗可以有效缓解化疗药物所产生的毒副作用，如胃肠道反应、骨髓抑制等[2-3]。……