榄香烯乳剂治疗中晚期肝癌的疗效与安全性的临床观察

郭鹏 朱为康 李雁 沈睿 陆俊骏 史文翡

摘要 目的：探討榄香烯乳剂联合TACE治疗中晚期肝癌的疗效与安全性。方法：选取2015年2月至2017年2月在上海中医药大学附属上海市中医医院肿瘤科收治的中晚期肝癌患者80例，将患者随机分为观察组（n=40）和对照组（n=40）。对照组给予TACE治疗，观察组在对照组的基础上联合榄香烯乳剂治疗。观察2组患者中医证侯疗效、肝功能、生命质量以及不良反应发生率。结果：观察组中医证侯改善率（80.00%）明显大于对照组（47.50%）（P<0.05）;观察组在改善患者ALT、AST、GGT、TBIL方面均优对照组（P<0.05）;观察组治疗后KPS评分（86.49±12.03）明显大于对照组（74.14±13.67）（t=4.289，P<0.05）;2组不良反应情况比较差异无统计学意义（P<0.05）。结论：榄香烯乳剂联合TACE治疗中晚期肝癌患者能明显改善患者中医临床症状、肝功能以及生命质量，而不良反应均可缓解，值得临床推广。

关键词 榄香烯乳剂;TACE治疗;中晚期肝癌;临床疗效;安全性

Clinical Observation on the Efficacy and Safety of Elemene Emulsion in the Treatment of Advanced Liver Cancer

Guo Peng， Zhu Weikang， Li Yan， Shen Rui， Lu Junjun， Shi Wenfei

（Department of Oncology， Shanghai Hospital of Traditional Chinese Medicine Affiliated

to Shanghai University of Traditional Chinese Medicine， Shanghai 200071， China）

Abstract Objective：To investigate the curative effect and safety of the elemenum emulsion combined with TACE treatment in treating the middle-late stage of liver cancer. Methods：A total of 80 cases of middle-late liver oncology who were treated in Shanghai university of traditional Chinese medicine affiliated hospital of traditional Chinese medicine from February 2015 to February 2015 were selected and randomly divided into observation group （n=40） and the control group （n=40）. The control group was given conventional treatment， and the observation group was given joint elemenum emulsion treatment on the basis of control group. TCM syndrome curative effect， liver function， quality of life and the incidence of adverse reactions of two groups were observed. Results：The improvement rate of TCM syndrome in observation group （80.00%） was significantly greater than the control group （47.50%） （P<0.05）; The improvement of ALT， AST， GGT， TBIL in observation group was better than control group （P<0.05）; after treatment， KPS score （86.49±12.03） of the observation group was significantly greater than the control group （74.14±13.67） （t=4.2.89， P<0.05）; The adverse reaction conditions were similar between the two groups， without statistical significance （P<0.05）. Conclusion：Elemenum emulsion combined with TACE in the treatment of patients with middle-late stage of liver cancer can significantly improve the clinical symptoms， liver function and quality of life， and adverse reactions can alleviate， which is worthy of clinical promotion.

Key Words Elemenum emulsion; TACE treatment; Middle-late stage liver cancer; Clinical curative effect; Safety

中图分类号：R242;R735.7文献标识码：Adoi：10.3969/j.issn.1673-7202.2018.03.033

原发性肝癌（Primary Carcinoma of Liver，PLC）是发生在肝脏内的恶性癌肿，其中90%为肝细胞性肝癌。我国每年约有11万人死于肝癌[1-3]。臨床上发现的肝癌约70%都属于中晚期[4-6]。中晚期肝癌患者大多数已发生转移，并且患者大部分有肝病既往史，因此79%左右的患者不可采取受手术治疗。肝动脉灌注化疗栓塞术（Transcatheter Arterial Chemoembolization，TACE）可引起肿瘤组织的缺血坏死。目前TACE治疗应用于肝癌的治疗较为多见[7-9]。然而由于肝癌易复发以及易转移的生物学特性和TACE治疗相对较高的不良反应，使单纯的TACE治疗方式被部分患者拒绝。榄香烯乳剂是从中草药中提取的抗癌物质，属于天然来源的抗肿瘤药物。其主要功能是抑制肿瘤细胞的生长、浸润以及转移，诱发肿瘤细胞凋亡。本研究为了探讨榄香烯乳剂联合TACE治疗中晚期肝癌的疗效与安全性，现报道如下。

1 资料与方法

1.1 一般资料 选取2015年2月至2017年2月在上海中医药大学附属上海市中医医院肿瘤科收治的80例中晚期肝癌患者。……