清瘟解毒汤联合阿奇霉素治疗小儿支原体肺炎的临床疗效探讨

陈宏超

[摘要] 目的 研究觀察清瘟解毒汤联合阿奇霉素治疗小儿支原体肺炎的临床疗效。方法 方便选择2017年1月—2018年1月期间在该院进行治疗的90例小儿支原体肺炎患者为对象展开研究，按患者治疗方式的不同随机分为观察组（n=45）和对照组（n=45），两组患者均进行常规的对症治疗，对照组在此基础上增加阿奇霉素治疗，观察组在对照组基础上清瘟解毒汤治疗。于治疗2周后对两组患者的临床疗效、症状消失时间及用药安全性进行评价比较。结果 观察组临床总有效率为91.11%（41/45），对照组为73.33%（33/45），组间比较差异有统计学意义（χ2=4.865，P=0.027）。观察组体温降至正常、喘息消失、咳嗽消失、肺部湿啰音消失胸部X线病灶吸收时间均低于对照组，组间差异有统计学意义（t=4.052、4.356、4.220、4.624，P=0.003、0.021、0.029、0.000）。观察组不良反应发生率为13.33%（6/45），对照组为6.67%（3/45），组间比较差异无统计学意义（χ2=1.111，P=0.292）。结论 清瘟解毒汤联合阿奇霉素治疗小儿支原体肺炎的临床疗效显著，能够改善患者的临床症状，且不良反应少，用药安全性好，有较高的临床应用价值。

[关键词] 支原体肺炎;阿奇霉素;清瘟解毒汤;临床疗效

[中图分类号] R725          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0172-03

Clinical Effect of Qingwenjiedu Decoction Combined with Azithromycin on Mycoplasma Pneumonia in Children

CHEN Hong-chao

Changle District Maternal and Child Health Hospital， Fuzhou， Fujian Province， 350200 China

[Abstract] Objective To observe the clinical efficacy of Qingwenjiedu Decoction combined with azithromycin in the treatment of mycoplasma pneumonia in children. Methods A total of 90 patients with mycoplasma pneumonia who were treated in the hospital between January 2017 and January 2018 were convenient selected. The patients were randomly divided into observation group （n=45） and control group （n=45）， both groups of patients were treated with routine symptomatic treatment. The control group was treated with azithromycin on the basis of this， and the observation group was treated with Qingwenjiedu Decoction on the basis of the control group. After 2 weeks of treatment， the clinical efficacy， symptom disappearance time， and drug safety of the two groups were evaluated and compared. Results The total effective rate was 91.11% （41/45） in the observation group and 73.33% （33/45） in the control group. The difference between the groups was statistically significant （χ2=4.865， P=0.027）. In the observation group， body temperature dropped to normal， wheezing disappeared， cough disappeared， and wet chest rales disappeared. The absorption time of chest X-ray lesions was lower than that of the control group， with significant differences between groups （t=4.052， 4.356， 4.220， 4.624， P=0.003， 0.021， 0.029， 0.000）. The incidence of adverse reactions was 13.33% （6/45） in the observation group and 6.67% （3/45） in the control group. There was no significant difference between the groups （χ2=1.111， P=0.292）. Conclusion Qingwenjiedu Decoction combined with azithromycin has significant clinical efficacy in the treatment of mycoplasma pneumonia in children. It can improve the clinical symptoms of patients， and has fewer adverse reactions. It is safe and has high clinical application value.

[Key words] Mycoplasma pneumonia; Azithromycin; Qingwenjiedu decoction; Clinical efficacy

支原体肺炎是儿童社区获得性肺炎中最为常见的一种，该病起病隐匿，表现为发热、咳嗽、气促等症状，进一步导致肺不张、气胸、纵膈积气、胸腔积液、坏死性肺炎、肺不张、呼吸窘迫等重度肺部症状，部分患儿有多系统受累，如心肌炎、心包炎、溶血性贫血、血小板减少、脑膜炎、肾炎等，严重威胁儿童患者的什么健康和生活质量[1]。……