不同剂量孕激素治疗月经稀发的临床效果

王智敬 肖建娇

【摘要】 目的：分析不同剂量孕激素治疗月经稀发的临床效果。方法：选取2018年1-6月笔者所在门诊接诊的月经稀发患者120例为研究对象，随机摸球法分为A组40例，采用6 mg/d孕激素治疗;B组40例，采用10 mg/d孕激素治疗;C组40例，采用15 mg/d孕激素治疗。对比不同剂量孕激素临床治疗效果。结果：三组临床总有效率对比，差异无统计学意义（P>0.05）;A组不良反应发生率显著低于B、C组，差异有统计学意义（P<0.05）;三组月经周期、月经量、子宫内膜厚度及月经经期对比，差异均无统计学意义（P>0.05）。结论：为月经稀发患者采用不同剂量孕激素治疗时，随剂量提升不良反应发生率持续上升，但治疗总有效率和月经量等指标并未出现较大变化。因此，低剂量孕激素更有应用价值。

【关键词】 月经稀发 不同剂量孕激素 临床疗效 不良反应

doi：10.14033/j.cnki.cfmr.2019.30.060 文献标识码 B 文章编号 1674-6805（2019）30-0-02

[Abstract] Objective： To analyze the clinical effect of different doses of Progesterone in the treatment of oligomenorrhea. Method： A total of 120 patients with oligomenorrhea who were admitted to our outpatient department from January to June 2018 were selected as research objects. According to touch ball method， 40 cases were divided into the group A and treated with 6 mg/d Progesterone. And 40 cases were divided into the group B and treated with 10 mg/d Progesterone. And 40 cases were divided into the group C and treated with 15 mg/d Progesterone. The clinical effects of different doses of Progesterone were compared. Result： The total clinical effective rate were compared among the three groups， and the difference was not statistically significant （P>0.05）. The incidence of adverse reactions in the group A was significantly lower than that of the group B and the group C， and the difference was statistically significant （P<0.05）. Menstrual cycle， menstrual volume， endometrial thickness and menstrual period were compared among the three groups， and the differences were not statistically significant （P>0.05）. Conclusion： When patients with Oligomenorrhea are treated with different doses of Progesterone， the adverse reactions continue to increase with the increase of the dose， but there are no significant change in the total effective rate and menstrual volume and other indicators. Therefore， the low dose of Progesterone has more application value.

[Key words] Oligomenorrhea Different doses of Progesterone Clinical efficacy Adverse reactions

First-authors address： The First Hospital of Putian， Putian 351100， China

隨着社会经济持续发展，女性在社会中承担的压力也逐渐增大。精神紧张和营养失衡等不良因素常会使得女性卵巢、垂体功能受到不良影响，继而造成机体内分泌失调，出现月经失调等症状。月经稀发多发于青春期或中年女性患者，临床多表现为月经周期后延，可伴有月经量异常，部分患者还可能出现体重改变、情绪紧张、睡眠障碍等，对生活质量产生不良影响[1]。临床对月经稀发多采用孕激素治疗，但使用剂量尚无统一标准。为研究不同剂量孕激素的治疗效果，选取笔者所在医院接诊的月经稀发患者为研究对象，结果分析如下。

1 资料与方法

1.1 一般资料

选取2018年1-6月笔者所在门诊接诊的月经稀发患者120例。纳入标准：（1）所有患者均符合月经稀发诊断标准;（2）连续3个月月经周期>35 d，黄体期血清孕酮<9.51 nmol/L;（3）子宫和双侧附件正常。排除标准：（1）器质性病变引发的月经不调;（2）严重内分泌疾病、血液疾病;（3）肝肾功能异常;（4）哺乳期、妊娠期;（5）有黄体酮药物禁忌证。随机摸球法分为A组40例，年龄22～48岁，平均（37.52±3.26）岁;月经周期36～56 d，平均（41±1）d。B组40例，年龄23～49岁，平均（37.67±3.32）岁;月经周期36～55 d，平均（41±3）d。C组40例，年龄23～48岁，平均（37.45±3.27）岁;月经周期37～57 d平均（42±2）d。三组一般资料比较，差异均无统计学意义（P>0.05）。研究通……