丹红注射液辅助治疗椎基底动脉供血不足眩晕的可行性

黄旭冰 蔡雯靖 徐壁鑫

【摘要】 目的：探討丹红注射液辅助治疗椎基底动脉供血不足眩晕的可行性，评价其治疗效果。方法：选取2015年8月-2018年8月于本院就诊的椎基底动脉供血不足眩晕患者，按随机数字表法将患者分为对照组和观察组。在基础治疗的基础上，对照组患者给予口服氟桂利嗪治疗，观察组在对照组的基础上加用丹红注射液，对比两组患者治疗后的临床效果及治疗前后的眩晕评分、左右大脑前动脉血流速度（LVA、RVA）、基底动脉血流速度（BA）。结果：治疗后，观察组总有效率为93.02%，高于对照组的73.17%，差异有统计学意义（P<0.05）。治疗后，两组患者的眩晕评分均显著低于治疗前，且观察组患者的眩晕评分低于对照组，差异均有统计学意义（P<0.05）。治疗前，两组患者的LVA、RVA及BA比较，差异均无统计学意义（P>0.05）;治疗后，观察组患者的LVA、RVA及BA均高于对照组，差异均有统计学意义（P<0.05）。治疗后，观察组0～2 h及3～6 h的起效率均高于对照组，差异均有统计学意义（P<0.05）。结论：丹红注射液能有效改善椎基底动脉供血不足的眩晕症状，增加椎基底动脉血流量，疗效显著，值得临床推广。

【关键词】 丹红注射液; 氟桂利嗪; 椎基底动脉供血不足; 眩晕

【Abstract】 Objective：To explore the feasibility of Danhong Injection in the treatment of vertigo caused by vertebrobasilar insufficiency and evaluate its therapeutic effect.Method：Patients with vertebrobasilar insufficiency vertigo who were treated in our hospital from August 2015 to August 2018 were enrolled.The patients were divided into observation group and control group according to the random number table.The control group was treated with Flunarizine orally，and the observation group was treated with Danhong Injection on the basis of the control group.The clinical efficacy after treatment，vertigo score before and after treatment and blood flow velocity of left and right anterior cerebral arteries（LVA and RVA）and basilar artery（BA）were compared between the two groups.Result：After treatment，the total effective rate of the observation group was 93.02%，higher than 73.17% of the control group，the difference was statistically significant（P<0.05）.After treatment，the vertigo scores of patients in both groups were significantly lower than those before treatment，and the vertigo score of patients in the observation group was lower than that in the control group，with statistically significant differences（P<0.05）.Before treatment，LVA，RVA and BA of the two groups showed no significant differences（P>0.05）;after treatment，LVA，RVA and BA in the observation group were higher than those in the control group，the differences were statistically significant（P<0.05）.After treatment，the starting efficiency of the observation group at 0-2 h and 3-6 h were higher than those of the control group，the differences were statistically significant（P<0.05）.Conclusion：Danhong Injection can effectively improve the symptoms of vertigo caused by insufficient blood supply to the vertebrobasilar artery and increase the blood flow to the vertebrobasilar artery.

【Key words】 Danhong Injection; Flunarizine; Vertebrobasilar insufficiency; Vertigo

First-authors address：Ciyun Hospital of Jieyang City，Jieyang 522000，China

doi：10.3969/j.issn.1674-4985.2019.08.003

椎基底动脉供血不足是临床上常见的心脑血管疾病，主要是各种因素使椎基底动脉产生痉挛或粥样硬化，从而使血流通过缓慢，进而造成脑组织相对的供血不足[1]。临床上主要以眩晕、恶心呕吐为主要表现。随着人们生活水平的提高，椎基底动脉供血不足的发病率呈逐年上升趋势[2]。该病治疗早期以内科治疗为主，主要是抗凝、控制血压、血糖、血脂等，对于内科治疗效果不佳的患者，采取手术治疗，主要以扩张血管为主[3]，目的是恢复脑组织的血流供应，改善患者临床症状[4]。然而，治疗效果不能完全令人满意，同时随着用药而产生的副作用也不容忽视[5]。丹红注射液是中医常见活血药物，主要成分为丹参、红花，具有通脉舒络、活血化瘀的功能，在临床得到了较多的关注[6]。……