吡拉西坦氯化钠注射液联合神经节苷脂治疗急性脑出血的疗效研究

马亨曼

【摘要】 目的：探讨吡拉西坦氯化钠注射液与神经节苷脂联合治疗对急性脑出血患者的临床效果。方法：选取2017年6月1日-2018年6月30日在本院接受治疗的急性脑出血患者74例为研究对象。按照治疗方法不同将其分为观察组和对照组，各37例。两组均行常规检查及治疗，在此基础上，对照组给予神经节苷脂治疗，观察组给予吡拉西坦氯化钠注射液与神经节苷脂联合治疗。比较两组精神状态（MMSE评分）、认知情况（MoCA评分）、神经功能（NIHSS评分）、血清铁蛋白含量、脑水肿体积及治疗效果。结果：治疗后，观察组MMSE、MoCA评分均高于对照组，NIHSS评分低于对照组，差异均有统计学意义（P<0.05）;观察组血清铁蛋白含量及脑水肿体积均少于对照组（P<0.05）;观察组总有效率为97.30%，高于对照组的72.97%（P<0.05）。结论：给予急性脑出血患者实行吡拉西坦氯化钠注射液與神经节苷脂联合治疗可促进神经功能恢复，提高认知功能，有较高的临床应用价值。

【关键词】 急性脑出血; 吡拉西坦氯化钠注射液; 神经节苷脂

【Abstract】 Objective：To investigate the clinical effect of Piracetam Sodium Chloride Injection combined with Ganglioside in treatment of acute cerebral hemorrhage.Method：A total of 74 patients with acute cerebral hemorrhage treated in our hospital from June 1，2017 to June 30，2018 were selected as the study subjects.According to different treatment methods，they were divided into observation group and control group，37 cases in each group.On the basis of routine examination and treatment，the control group was treated with Ganglioside，while the observation group was treated with Piracetam Sodium Chloride Injection combined with Ganglioside.The mental status（MMSE score），cognitive status（MoCA score），neurological function（NIHSS score），serum ferritin content，brain edema volume and therapeutic effect between two groups were compared.Result：After treatment，the scores of MMSE and MoCA in observation group were higher than those of control group，while the scores of NIHSS were lower than those of control group，the differences were statistically significant（P<0.05）.The content of serum ferritin and the volume of brain edema in observation group were less than those of control group（P<0.05）.The total effective rate was 97.30% in observation group，which was higher than 72.97% in control group（P<0.05）.Conclusion：The combination therapy of Piracetam Sodium Chloride Injection combined with Ganglioside in patients with acute cerebral hemorrhage can promote the recovery of nerve function and improve cognitive function，which has high clinical application value.

【Key words】 Acute cerebral hemorrhage; Piracetam Sodium Chloride Injection; Ganglioside

First-authors address：Second Hospital of Chaoyang City，Chaoyang 122000，China

doi：10.3969/j.issn.1674-4985.2019.08.037

急性脑出血的主要临床表现为突然昏仆、肢体偏瘫、语言障碍、口舌歪斜以及不省人事等，出血部位以及出血量直接影响到患者的预后效果，及时有效的治疗可缩短脑组织缺血缺氧时间，降低神经中枢功能受损程度，提高患者认知功能[1-2]。现为了探究将吡拉西坦氯化钠注射液与神经节苷脂联合治疗应用于该疾病患者的治疗中的临床效果，特选取74例在本院接受治疗的该疾病患者（入院时间为2017年6月1日-2018年6月30日）作为临床研究对象，探究其临床应用效果。现报道如下。

1 资料与方法

1.1 一般资料 选取2017年6月1日-2018年6月30日在本院接受治疗的急性脑出血患者74例为研究对象。纳入标准：经头颅CT确诊并接受对症支持、保护脑细胞、血压逐渐控制在160/90 mm Hg左右以及脱水剂降低颅内压治疗;发病后24 h内入院，且入院前未接受任何治疗;均为首次自发性脑出血[3]。……