壳聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎的临床疗效分析

刘少晓 赖晓珺 林雪芳

[摘要] 目的 研究殼聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎的临床疗效。 方法 2018年2月～2019年3月选取非淋菌性宫颈炎患者92例，按照随机数字法分为两组，每组46例。观察组应用壳聚糖宫颈抗菌膜联合多西环素治疗，对照组应用多西环素单纯治疗，均治疗8周，对比两组的治疗效果、不良反应发生率、T淋巴细胞亚群及患者治疗满意度。 结果 观察组治疗总有效率为95.65%，明显高于对照组（69.57%），差异具有统计学意义（P<0.05）;观察组恶心呕吐、纳差、腹泻、发热等不良反应的发生率为8.68%，明显低于对照组（28.25%），差异具有统计学意义（P<0.05）;观察组患者满意度为97.83%，明显高于对照组（76.09%），差异具有统计学意义（P<0.05）;治疗前，两组患者的CD3+、CD4+、CD8+和CD4+/CD8+水平比较，差异无统计学意义（P>0.05），治疗后两组患者CD3+、CD4+、CD8+均明显升高，而CD4+/CD8+明显降低，差异具有统计学意义（P<0.05），其中观察组CD3+、CD4+、CD8+明显高于对照组，而CD4+/CD8+明显低于对照组，差异具有统计学意义（P<0.05）。 结论 壳聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎的临床疗效显著，值得推广应用。

[关键词] 壳聚糖宫颈抗菌膜;多西环素;非淋菌性宫颈炎;临床疗效

[中图分类号] R711.32          [文献标识码] B          [文章编号] 1673-9701（2020）16-0047-04

Clinical efficacy analysis of chitosan cervical antibacterial membrane combined with doxycycline in the treatment of non-gonococcal cervicitis

LIU Shaoxiao   LAI Xiaojun   LIN Xuefang

Department of Obstetrics and Gynecology， Lishui People's Hospital in Zhejiang Province，Lishui   323000，China

[Abstract] Objective To study the clinical effect of chitosan cervical antibacterial membrane combined with doxycycline on non-gonococcal cervicitis. Methods From February 2018 to March 2019， 92 patients with nongonococcal cervicitis were selected and divided into two groups according to the random number rule， 46 patients in each group. The observation group was treated with chitosan cervical antibacterial membrane combined with doxycycline， while the control group was treated with doxycycline alone for 8 weeks. Then the therapeutic effect， incidence of adverse reactions， T lymphocyte subsets and treatment satisfaction were compared. Results the total effective rate of the observation group was 95.65%， significantly higher than that of the control group（69.57%）， and the difference was statistically significant （P<0.05）. the incidence rate of adverse reactions such as nausea， vomiting， anorexia， diarrhea and fever in the observation group was 8.68%， significantly lower than that of the control group（28.25%）， and the difference was statistically significant（P<0.05）. The satisfaction of the observation group was 97.83%， significantly higher than that of the control group（76.09%）， and the difference was statistically significant（P<0.05）. Before treatment， there was no significant difference in CD3+， CD4+， CD8+ and CD4+/CD8+ between the two groups（P>0.05）. After treatment， CD3+， CD4+， CD8+ in the two groups were significantly increased， while CD4+/CD8+ was significantly decreased， with significant difference（P<0.05）. CD3+， CD4+， CD8+ in the observation group was significantly higher than that in the control group， while CD4+/CD8+ was significantly lower than that in the control group， with significant difference（P<0.05）. Conclusion Chitosan cervical antibacterial membrane combined with doxycycline had a significant clinical effect in the treatment of nongonococcal cervicitis， which was worthy of further promotion and application.

[Key words] Chitosan cervical antibacterial membrane; Doxycycline; Non-gonococcal cervicitis; Clinical efficacy

非淋菌性宫颈炎是一种临床常见的妇科疾病，具有一定的传染性，且容易复发，对患者的身体健康和生活质量都有较大影响[1]。非淋菌性宫颈炎主要由支原体和沙眼衣原体感染导致，但由于临床相关药物使用过多，细菌耐药性较高，故单一用药疗效较差，无法满足患者需求[2]。根据相关研究，壳聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎临床效果较好，且不良反应发生较少[3]。本研究也针对壳聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎的临床疗效进行分析，现报道如下。

1 资料与方法

1.1 临床资料

选择2018年2月～2019年3月丽水市人民医院收治的92例非淋菌性宫颈炎患者，根据不同治疗方式将患者分为两组，见表1。其中观察组46例，年龄21～47岁，平均年龄（33.16±1.09）岁，平均病程（4.16±0.34）个月;对照组46例，年龄20～46岁，平均年龄（33.12±1.07）岁，平均病程（4.21±0.31）个月。……