PRF联合Dycal在年轻恒牙直接盖髓术中临床疗效分析

崔兴萌 胡光耀

[摘要] 目的 通过观察深龋去腐过程中意外露髓的年轻恒牙应用PRF联合Dycal和单纯使用Dycal直接盖髓的临床疗效，探讨PRF联合Dycal作为直接盖髓材料在年轻恒牙中的临床疗效。 方法 方便选择2018年1—7月于该院就诊的7～14岁患者中60例深龋意外露髓的年轻恒牙，随机的分为两组，试验组：PRF/Dycal直接盖髓组;对照组：Dycal直接盖髓组，两组直接盖髓后均使用玻璃离子垫底，继而复合树脂充填。随访两组，分析对比12个月后的直接盖髓成功率。 结果 术后12个月后，试验组PRF/Dycal和对照组Dycal治疗成功率为93.33%和66.67%，两组间差异有统计学意义（χ2=5.104，P<0.05）。 结论 PRF联合Dycal行直接盖髓术，比单独使用Dycal效果更显著，其联合使用可以作为PRF在年轻恒牙直接盖髓术中的更为有效的方法。

[关键词] PRF;Dycal;直接盖髓术;临床疗效

[Abstract] Objective To observe the clinical effects of PRF combined with Dycal and Dycal directly on the pulp of young permanent teeth that accidentally exposed the pulp during the process of deep caries removal， and to explore the clinical application of PRF and Dycal as direct pulp filling materials in young permanent teeth curative effect. Methods A total of 60 young permanent teeth with a deep caries accidentally exposed in the 7 to 14-year-old patient who were treated in the hospital from January to July 2018 were convenient selection randomly divided into two groups. The test group was the PRF/Dycal direct pulp capping group and the control group. ： Dycal direct capping group. Both groups used glass ion pad after direct capping， and then filled with composite resin. Two groups were followed up， and the success rate of direct pulp capping after 12 months was analyzed and compared. Results After 12 months， the success rates of PRF/Dycal and Dycal in the control group were 93.33% and 66.67%. The difference between the two groups was statistically significant（χ2=5.104， P<0.05）. Conclusion PRF combined with Dycal for direct pulp capping is more effective than Dycal alone. Its combined use can be a more effective method for direct pulp capping in young permanent teeth.

[Key words] PRF; Dycal; Direct pulp capping; Clinical efficacy

牙髓具有自行修復的能力，当受到物理、化学等外界病原物刺激的作用而受到损伤时，恰当的牙髓保存治疗可促进牙髓组织的修复能力，继而形成修复性牙本质，达到保存牙髓的目的。良好的盖髓材料可以使健康的牙髓组织与外界的病原刺激物分隔，在保护已经暴露的牙髓组织基础之上，同时可以促进修复性牙本质的形成，为牙髓组织提供一个相对优良的环境，以利于其修复及再生[1]。随着学者不断的努力，以及对修复性牙本质研究的加深，越来越多保存活髓的盖髓材料接连出现，如氢氧化钙，MTA、iroot等[2-3]，虽然每种材料都有各自的优点，但相对应地也存在各自的弊端，因而至今仍尚缺乏一种理想的盖髓剂。

目前，越来越多的关于有机生物材料作为盖髓剂的研究出现。有文献认为，PRF作为一种制作简单，成本较低的有机生物材料，其内含有大量的生长因子，血小板及白细胞，同时具有逐步释放细胞因子的生物特性[4]。……