匹多莫德联合氨溴特罗治疗小儿急性支气管炎的临床疗效探究

刘强

[摘要] 目的 探討分析匹多莫德联合氨溴特罗治疗小儿急性支气管炎的临床疗效。方法 从该院2018年5月—2019年4月收治的小儿急性支气管炎患者中从中方便选取76例作为该次研究对象，分为两组，其中对照组38例为2018年5—10月收治的患儿，观察组38例为2018年11月—2019年4月收治的患儿。对照组仅给予氨溴特罗治疗，观察组在对照组基础上给予匹多莫德治疗，比较两组患儿不同用药方式的临床疗效、临床症状消失时间及不良反应发生情况。结果 两组的临床疗效相比，对照组患儿治疗总有效率81.58%（31/38）低于观察组患儿治疗总有效率97.37%（1/38），差异有统计学意义（χ2=6.125，P=0.015）;两组的临床症状消失时间相比，对照组患儿咳嗽消失时间晚于观察组患儿，差异有统计学意义（χ2=7.527，P=0.004），对照组患儿肺部啰音消失时间晚于观察组患儿，差异有统计学意义（χ2=6.519，P=0.027），两组患儿治疗期内均未发生任何不良反应。 结论 匹多莫德联合氨溴特罗治疗小儿急性支气管炎较单一使用氨溴特罗治疗，疗效更优、患儿临床症状消失时间更快，无任何不良反应，安全性高，有临床应用价值。

[关键词] 匹多莫德;氨溴特罗;急性支气管炎;临床疗效

[中图分类号] R725.6          [文献标识码] A          [文章编号] 1674-0742（2020）06（a）-0100-03

Study on the Clinical Efficacy of Pidotimod Combined with Ambroxol in the Treatment of Children with Acute Bronchitis

LIU Qiang

Department of Pediatrics， Maternal and Child Health Hospital， Linshu， Shandong Province， 276700 China

[Abstract] Objective To explore the clinical efficacy of pidotimod combined with ambrotrolol in the treatment of children with acute bronchitis. Methods From the pediatric patients with acute bronchitis treated in the hospital from May 2018 to April 2019， 76 patients were convenient selected as the research object and divided into two groups， of which 38 patients in the control group were from May to October 2018. 38 patients in the observation group were admitted from November 2018 to April 2019. The control group was given only ambroxol， and the observation group was given pidotimod on the basis of the control group. The clinical efficacy， time of disappearance of clinical symptoms， and adverse reactions of the two groups were compared. Results Compared with the clinical efficacy of the two groups， the total effective rate of treatment in the control group was 81.58% （31/38） lower than that in the observation group. The total effective rate was 97.37% （1/38）， and the difference was statistically significant （χ2=6.125，P=0.015）; compared with the clinical symptoms disappearing time of the two groups， the cough disappearing time of the children in the control group was later than that in the observation group， the difference was statistically significant （χ2=7.527，P=0.004）. The disappearance time of the children's lung rales was later than that of the observation group， and the difference was statistically significant （χ2=6.519，P=0.027）. No adverse reactions occurred in the two groups during the treatment period. Conclusion Pidotimod combined with ambrotrolide in the treatment of children with acute bronchitis is more effective than ambroxol alone. The clinical symptoms of children disappear faster， without any adverse reactions， high safety， and clinical application value.

[Key words] Pidotimod; Ambroxol; Acute bronchitis; Clinical efficacy

急性支气管炎是常见的儿科呼吸系统疾病，多发生在儿童时期，主要以婴幼儿多见。该病是由各种病原体，如病毒、细菌、支原体等引起的支气管黏膜感染、水肿所致。临床症状主要表现为一般先有上呼吸道感染的症状，如发热、头痛、鼻塞、打喷嚏、乏力等症状，随后就会出现咳嗽，咳嗽是主要的症状。……