刘开林


【摘要】 目的 探討经鼻高流量加温湿化吸氧治疗慢性阻塞性肺疾病(COPD)并呼吸衰竭患者的效果。方法 80例COPD并呼吸衰竭患者, 采用随机数字表法分为对照组和研究组, 每组40例。对照组使用低流量鼻导管氧气吸入治疗, 研究组使用经鼻高流量加温湿化吸氧治疗。对比两组心率、呼吸频率、血气分析指标、不良反应发生情况。结果 治疗前, 两组患者心率、呼吸频率对比差异无统计学意义(P>0.05)。治疗后, 两组心率对比差异无统计学意义(P>0.05);研究组呼吸频率(17.85±1.57)次/min低于对照组的(19.12±1.52)次/min, 差异具有统计学意义(P<0.05)。治疗后, 两组动脉血氧分压(PaO2)、pH对比差异无统计学意义(P>0.05);研究组动脉血二氧化碳分压(PaCO2)(44.50±5.85)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(48.41±8.26)mm Hg, 差异具有统计学意义(P<0.05)。研究组不良反应发生率为10.00%, 低于对照组的35.00%, 差异具有统计学意义(P<0.05)。结论 经鼻高流量加温湿化吸氧治疗COPD并呼吸衰竭患者的效果显著, 能够减慢呼吸频率, 改善二氧化碳潴留, 减少不良反应的发生。
【关键词】 经鼻高流量加温湿化吸氧;慢性阻塞性肺疾病;呼吸衰竭;心率
DOI:10.14163/j.cnki.11-5547/r.2020.28.008
Effect analysis of heated humidified high flow nasal cannulaoxygen therapy in the treatment of COPD patients with respiratory failure LIU Kai-lin. Department of Internal Medicine, Jieyang Puning Overseas Chinese Hospital, Jieyang 515300, China
【Abstract】 Objective To discuss the effect of heated humidified high flow nasal cannulaoxygen therapy in the treatment of chronic obstructive pulmonary disease (COPD) patients with respiratory failure. Methods A total of 80 COPD patients with respiratory failure were divided into control group and research group according to random numerical table, with 40 cases in each group. The control group was treated with low-flow nasal cannula oxygen inhalation, and the research group was treated with heated humidified high flow nasal cannulaoxygen therapy. The heart rate, respiratory rate, blood gas analysis index, occurrence of adverse reactions were compared between the two groups. Results Before treatment, there was no statistically significant difference in heart rate, respiratory rate between the two groups (P>0.05). After treatment, there was no statistically significant difference in heart rate between the two groups (P>0.05). The respiratory rate (17.85±1.57) times/min of the research group was lower than (19.12±1.52) times/min of the control group, and the difference was statistically significant (P<0.05). After treatment, there was no statistically significant difference in arterial partial pressure of oxygen (PaO2), pH between the two groups (P>0.05). Arterial partial pressure of carbon dioxide (PaCO2) (44.50±5.85) mm Hg(1 mm Hg=0.133 kPa) of the research group was lower than (48.41±8.26) mm Hg of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions of the research group was 10.00%, which was lower than 35.00% of the control group, and the difference was statistically significant (P<0.05). Conclusion Heated humidified high flow nasal cannulaoxygen therapy shows remarkable effect for COPD patients with respiratory failure, which can slow down breathing rate, improve carbon dioxide retention and reduce the occurrence of adverse reactions.
【Key words】 Heated humidified high flow nasal cannulaoxygen therapy; Chronic obstructive pulmonary disease; Respiratory failure; Heart rate
COPD为临床常见的呼吸系统疾病, 具有反复发作、病死率高的特点[1]。COPD的患者由于长期处于病變状态, 肺功能严重下降影响供氧, 较多的COPD患者可伴有呼吸衰竭, 加重病情, 影响治疗效果[2]。目前COPD并呼吸衰竭的早期治疗主要以呼吸支持治疗为主, 经鼻吸氧具有较高的舒适性, 是目前常用的吸氧方法。但COPD并呼吸衰竭患者吸入的氧流量较大, 常规鼻导管吸氧, 由于湿化不佳, 高流量的干冷气体易引发患者的不适[3]。经鼻高流量加温湿化吸氧通过适当加温加湿吸入的气体, 降低患者的不适感, 经鼻高流量加温湿化吸氧治疗COPD并呼吸衰竭患者的效果或许更佳, 现报告如下。
1 资料与方法
1. 1 一般资料 选择2018年1月~2020年2月本院收治的80例COPD并呼吸衰竭患者作为研究对象, 采用随机数字表法分为对照组和研究组, 每组40例。对照组患……