前列地尔辅助超早期肠内营养治疗重症急性胰腺炎及对患者炎症因子水平的影响

洪凯 唐帅

【摘要】目的：研究探讨前列地尔联合超早期肠内营养对重症急性胰腺炎的疗效。方法：选取2018年2月至2021年2月在韶关市第一人民医院消化内科80例重症胰腺炎患者分为观察组、对照组，各 40例。对照组给予超早期肠内营养干预，观察组在对照组基础上增加前列地尔治疗。对两组患者的临床疗效、症状缓解时间、炎症因子、不良反应发生率等进行统计比较。结果：观察组、对照组总有效率分别为90.00%（36/40）、70.00%（28/40），对比差异有统计学意义（P <0.05）。观察组血淀粉酶恢复、腹痛消退、肠道功能恢复及住院时间均低于对照组（P <0.05）。观察组患者的炎症因子包括血清降钙素原（PCT）、C 反应蛋白（CRP）水平均低于对照组（P <0.05）。治疗期间两组患者的不良反应发生情况比较无统计学意义（P >0.05）。结论：前列地尔联合超早期肠内营养对重症急性胰腺炎患者的应用效果良好，有效促进患者的症状在较短时间内消退，有助于患者的快速康复，并可抑制机体的炎症反应水平，且治疗方案的安全性较高。

【关键词】重症胰腺炎;超早期腸内营养;前列地尔;临床疗效

【中图分类号】R657.5+1【文献标识码】A 【文章编号】2096-5249（2021）18-0015-03

Alprostadil assisted ultra early enteral nutrition in the treatment of se- vere acute pancreatitis and its effect on the level of inflammatory factors

Hong Kai， Tang Shuai

Department of Gastroenterology，Shaoguan first people's Hospital，Shaoguan 512000， China

【Abstract】Objective：To investigate the effect of alprostadil combined with ultra early enteral nutrition on severe acute pan- creatitis.Method：Eighty patients with severe pancreatitis in department of Gastroenterology，Shaoguan First People's Hospital from February 2018 to February 2021 were selected and divided into observation group and control group，with 40 cases in each group.The control group was given ultra-early enteral nutrition intervention，and the observation group was given alprostadil treatment based on the control group.Clinical efficacy，symptom relief time，inflammatory factors and incidence of adverse reactions were statisti- cally compared between the two groups.Result：The total effective rate of observation group and control group was 90.00%（36/40） and 70.00%（28/40），respectively，and the difference was statistically significant（P<0.05），The serum amylase recovery，abdomi- nal pain regression，intestinal function recovery and hospitalization time in the observation group were lower than those in the control group（P<0.05）.The levels of inflammatory factors including serum procalcitonin（PCT）and C-reactive protein（CRP） in observa- tion group were lower than those in control group（P<0.05）.There was no statistically significant difference in the occurrence of ad- verse reactions between the two groups during treatment（P>0.05）.Conclusion：The application effect of alprostadil combined with ultra-early enteral nutrition in patients with severe acute pancreatitis is good，which can effectively promote the regression of patients' symptoms in a short time，contribute to the rapid recovery of patients，and inhibit the level of inflammatory response in the body，and the safety of the treatment plan is high.

【Key words】Severe pancreatitis;Ultra-early enteral nutrition;Alprostadil;Clinical curative effect

重症胰腺炎是胰腺组织出现的炎症性损伤疾病，是由于各种因素导致的胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应[1]。患者发病后通常表现为恶心、呕吐、腹痛、腹泻、发热等症状，患者的血象主要表现在胰淀粉酶水平的异常升高。急性胰腺炎具有发病急促、病情进展快、病情严重等特点[2]。……