文拉法辛用于治疗抑郁症行无抽搐电休克治疗 (MECT) 后睡眠障碍患者的效果探讨

吴昱 王娟 黄仁春

【摘要】目的：研究文拉法辛用于治疗抑郁症行无抽搐电休克治疗（MECT）后导致的睡眠障碍患者的效果分析。方法：选取于我院就诊的60例抑郁症患者，随机分为对照组和观察组两组;对照组行 MECT和常规治疗，观察组在对照组各项措施基础上加文拉法辛治疗;经2周治疗后比较2组患者治疗前后用 PSQI评估睡眠质量。结果：两组治疗后睡眠质量评分均下降（P<O.05），观察组下降幅度大于对照组（P<0.05）。结论：对于抑郁症患者用无抽搐电休克治疗（MECT）后导致的睡眠障碍，联合文拉法辛治疗后，对减轻 MECT疗后睡眠障碍疗效确切。

【关键词】文拉法辛;抑郁症;无抽搐电休克治疗;睡眠障碍

[中图分类号]R749.4[文献标识码]A[文章编号]2096-5249（2021）21-0074-02

Efficacy ofVenlafaxine in the Treatment ofDepression Patients with Sleep Disorders after MECT

WU Yu1， WANG Juan 1， HUANG Ren-chun 2（1. Pharmacy Department， Fujian Fuzhou Neuropsychiatric Hospital， Fuzhou Fujian 350008， China;2. Psychiatry Department，Fujian Fuzhou Neuropsychiatric Hospital， Fuzhou Fujian 350008， China）

[Abstract] Objective： To study the effect of venlafaxine in the treatment of depression patients with sleep disorder caused by MECT. Methods：60 patients with depression in our hospital were randomly divided into control group and observation group. The control group was treated with MECT and routine treatment， and the observation group was treated with venlafaxine on the basis of various measures in the control group; after 2 weeks of treatment， the sleep quality of the two groups was evaluated by PSQI before and after treatment. Results： After treatment， the sleep quality scores of the two groups were decreased（P<0.05）， and the decline in the observation group was greater than that in the control group（P<0.05）. Conclusion： Combined with venlafaxine， it is effective to reduce sleep disorder after MECT in patients with depression.

[Key words] venlafaxine; depression; modified electroconvulsive therapy; sleep disorder

约有30% ～50%的难治性抑郁症患者经抗抑郁药治疗后疗效不满意或疗效不稳定[1]。无抽搐电休克治疗（Modified Electroconvulsive Therapy，MECT）[2]也称为改良电休克，是在传统电休克治疗的基础上，加用静脉麻醉药和肌肉松弛剂，并增加了全程给氧，监测惊厥的发作。MECT 是治疗难治性抑郁症急性期的常用方法，其运用一定的电流对大脑实施适量脉冲电流刺激，致使患者大脑皮质产生癫痫样放电来治疗相关疾病。有研究 [3]表明 MECT 因其直接作用于头部，故部分患者 MECT 療后常见的并发症包括睡眠障碍、头痛、可逆性的记忆减退、短暂的轻度发热等。本研究旨在观察抑郁症患者对其行无抽搐电休克治疗（MECT）后的睡眠障碍症状，在文拉法辛用药基础上评估其睡眠质量以观察效果，其具体报告见以下。

1 资料与方法