电子计算机断层扫描联合MRI对肺腺癌临床疗效的评估价值研究

何慧芬 徐晓晓 张敏鸽

[摘要] 目的 探讨电子计算机断层扫描（CT）联合磁共振成像（MRI）对肺腺癌临床疗效的评估价值。 方法 选取2019年3—8月我院病理学诊断确诊的肺腺癌患者80例，均进行放、化疗。治疗前后进行CT、MRI检查，根据治疗效果分为缓解组、未缓解组，比较两组CT检查密度及MRI检查参数值，比较各种检查方式诊断效能。结果 治疗后，与未缓解组比较，缓解组患者0、25、60 s时CT检查密度、MSI值较低，ADC、NEI值水平较高（P<0.05）。与CT检查、MRI检查相比，CT、MRI联合检查阳性预测率、阴性预测率、灵敏度、特异度、准确度较高（P<0.05）。 结论 使用CT联合MRI对肺腺癌患者临床疗效进行评价，阳性预测率、阴性预测率较高，诊断效能较为理想，具有一定的临床应用价值。

[关键词] 肺腺癌;电子计算机断层扫描;磁共振成像;化疗;放疗

[中图分类号] R734.2          [文献标识码] B          [文章编号] 1673-9701（2021）34-0116-04

[Abstract] Objective To explore the value of computed tomography（CT） combined with magnetic resonance imaging （MRI） in evaluating the clinical efficacy of lung adenocarcinoma. Methods A total of 80 patients with lung adenocarcinoma diagnosed by pathology in our hospital from March to August 2019 were treated with radiotherapy and chemotherapy. Patients were examined by CT and MRI before and after treatment. According to the treatment effect， patients were divided into two groups： the remission group and non-remission group. CT density and the parameters of MRI were compared between the two groups. The diagnostic efficiency of the two examination methods was compared. Results After treatment， the CT density and MSI value at 0， 25 and 60 s were lower， while the levels of ADC and NEI were higher in the remission group than those in the non-remission group （P<0.05）. Compared with CT and MRI alone， the combination of CT and MRI had higher positive predictive rate， negative predictive rate， sensitivity， specificity and accuracy （P<0.05）. Conclusion In the evaluation of clinical efficacy of patients with lung adenocarcinoma， the combination of CT and MRI has higher positive predictive rate and negative predictive rate， and good diagnostic efficiency， which has a certain clinical application value.

[Key words] Lung adenocarcinoma; Computed tomography; Magnetic resonance imaging; Chemotherapy; Radiotherapy

臨床医学将发生于机体肺组织的恶性肿瘤统称为肺腺癌[1-2]。据世界卫生组织调查数据显示，肺腺癌发病率、病死率均高居十大恶性肿瘤前两位，并且肺腺癌发病具有明显的性别差异，男性患者肺腺癌发病率、病死率明显高于女性[3]。影像学诊断为临床最为常用的诊断肺腺癌的手段，包括电子计算机断层扫描（CT）、磁共振成像（MRI）等[4-5]，但是目前将CT联合MRI检查应用于肺腺癌患者治疗后疗效评估中的研究还相对较少。本研究中使用CT联合MRI对肺腺癌患者治疗后进行检查，旨在探讨二者联合对肺腺癌患者治疗后临床疗效的评估价值。

1 资料与方法

1.1 一般资料

选取2019年3—8月我院收治的肺腺癌患者80例，所有患者均经我院病理学诊断确诊为肺腺癌，均进行放、化疗。80例肺腺癌患者包括男52例，女28例，年龄62～73岁，平均（67.5±4.4）岁，病程1～3个月，平均（2.1±0.8）个月。另选取2019年6月至2020年6月于我院体检的健康志愿者50名进行对照。本研究所有研究对象均知情同意，并获我院医学伦理委员会批准。……