陈芮 李淑云 陈玉娇



【摘要】 目的:探讨高龄产妇发生妊娠期糖尿病(GDM)的相关危险因素。方法:回顾性分析2018年1月-2020年3月本院收治的89例高龄产妇的临床资料,按照其是否发生GDM分为GDM组(n=17)和非GDM组(n=72)。分析高龄产妇发生GDM的相关危险因素。结果:89例高龄孕妇中发生GDM的有19.10%(17/89)。两组孕前BMI、糖尿病家族史、血红蛋白、日常运动量、睡眠时间、FPG比较,差异均有统计学意义(P<0.05)。两组年龄、文化程度、既往代谢疾病史、流产次数比较,差异均无统计学意义(P>0.05)。多因素logistic回归分析显示,孕前BMI≥24 kg/m2、糖尿病家族史、血红蛋白≥130 g/L、日常运动量<1 h/d、睡眠时间<7 h/d、空腹血糖(FPG)≥6.1 mmol/L是高龄产妇发生GDM的高危因素(P<0.05)。结论:高龄产妇发生GDM是多种因素共同作用结果,临床需针对各危险因素制定相应的干预措施,以降低GDM发生率。
【关键词】 妊娠期糖尿病 高龄产妇 空腹血糖
Related Risk Factors of Gestational Diabetes Mellitus in Elderly Parturient Analysis/CHEN Rui, LI Shuyun, CHEN Yujiao. //Medical Innovation of China, 2021, 18(31): -154
[Abstract] Objective: To explore the related risk factors of gestational diabetes mellitus (GDM) in elderly parturient. Method: The clinical data of 89 elderly parturient admitted to our hospital from January 2018 to March 2020 were retrospective analyzed. They were divided into GDM group (n=17) and non-GDM group (n=72) according to whether they had GDM. Analyzed the risk factors of GDM in elderly parturient. Result: GDM occurred in 19.10% (17/89) of 89 elderly parturient. There were statistically significant differences in pre-pregnancy BMI, family history of diabetes, hemoglobin, daily exercise, sleep time and FPG between two groups (P<0.05). There were no significant differences in age, education level, history of metabolic diseases and number of abortions between two groups (P>0.05). Multivariate logistic regression analysis showed that pre-pregnancy BMI≥24 kg/m2, family history of diabetes, hemoglobin≥130 g/L, daily exercise<1 h/d, sleep time<7 h/d, fasting blood glucose (FPG)≥6.1 mmol/L were the risk factors for GDM in elderly parturient (P<0.05). Conclusion: The occurrence of GDM in elderly parturient is the result of a combination of multiple factors, clinical interventions should be formulated for each risk factor to reduce the incidence of GDM.
[Key words] Gestational diabetes mellitus Elderly parturient Fast blood glucose
First-author’s address: Luoding Maternity and Child Health Hospital, Luoding 527200, China
doi:10.3969/j.issn.1674-4985.2021.31.036
妊娠期糖尿病(GDM)是一種妊娠前糖代谢正常或有潜在糖耐量减退,在妊娠期发现的糖尿病的代谢紊乱综合征[1]。GDM属高危妊娠,若不及时控制,既影响母体自身健康,也会诱发妊娠期高血压、急性羊水过多、巨大胎儿、胎儿窘迫、流产等不良妊娠结局,甚至威胁生命安全[2-3]。另外,约有50%的GDM患者妊娠结束后会进一步发展为2型糖尿病,且后代在青少年时期易出现糖耐量异常、肥胖,成年后易患高血压、糖尿病、冠心病等[4-6]。可见GDM的发生关系到流行病学的发展趋势,影响我国今后人口的素质。随着我国二胎政策的开放,高龄产妇比例日益增多,其各项生殖功能存在不同程度的减退,增加GDM发生风险。……