头孢他啶联合左氧氟沙星治疗老年心衰合并肺部感染的效果及对血清WBC、PCT的影响

肖海凤

【摘要】 目的：探究頭孢他啶联合左氧氟沙星治疗老年心衰（HF）合并肺部感染的效果及对血清WBC、PCT的影响。方法：选取本院2017年3月-2020年3月收治的HF合并肺部感染的老年患者76例为研究对象。采用随机数字表法将患者分为联合组和对照组，每组38例。对照组采用头孢他啶治疗，联合组在对照组的基础上加用左氧氟沙星治疗。比较两组患者血液指标、心功能指标水平，比较两组病原菌清除情况。结果：治疗后，两组的IL-6、TNF-α、BNP、WBC、PCT水平均显著低于治疗前，且联合组上述指标均显著低于对照组，差异均有统计学意义（P<0.05）。治疗后，两组LVESD、LVEDD、LVDs水平均显著低于治疗前，且联合组上述指标均低于对照组（P<0.05）;治疗后，两组LVEF均显著高于治疗前，且联合组高于对照组（P<0.05）。联合组病原菌清除率为70.7%，显著高于对照组的47.4%，差异有统计学意义（P<0.05）。治疗后，联合组的总有效率为92.11%，显著高于对照组的71.05%，差异有统计学意义（P<0.05）。结论：头孢他啶联合左氧氟沙星治疗老年HF合并肺部感染效果较好，不仅可有效地清除病原菌，降低血清中WBC、PCT水平，还能改善患者的肺部感染和心脏功能。

【关键词】 头孢他啶 左氧氟沙星 HF 肺部感染 WBC PCT

Effect of Ceftazidime Combined with Levofloxacin in the Treatment of Senile Heart Failure Complicated with Pulmonary Infection and Its Influence on Serum WBC and PCT/XIAO Haifeng. //Medical Innovation of China， 2021， 18（16）： 0-046

[Abstract] Objective： To explore the effect of Ceftazidime combined with Levofloxacin in the treatment of elderly heart failure （HF） complicated with pulmonary infection and its influence on serum WBC and PCT. Method： A total of 76 elderly patients with HF complicated with pulmonary infection admitted to our hospital from March 2017 to March 2020 were selected as the research subjects. The patients were divided into combined group and control group by random number table method， 38 cases in each group. The control group was treated with Ceftazidime and the combined group was treated with Levofloxacin on the basis of the control group. Blood indexes and heart function indexes were compared between the two groups， and pathogenic bacteria clearance was compared between the two groups. Result： After treatment， the levels of IL-6， TNF-α， BNP， WBC and PCT in both groups were significantly lower than those of before treatment， and the above indexes in the combination group were significantly lower than those in the control group， the differences were statistically significant （P<0.05）. After treatment， the levels of LVESD， LVEDD and LVDs in both groups were significantly lower than those of before treatment， and the above indexes in combined group were lower than those in control group （P<0.05）. After treatment， LVEF in both groups were significantly higher than before treatment， and combined group was higher than control group （P<0.05）. The clearance rate of pathogenic bacteria in the combined group was 70.7%， significantly higher than 47.4% in the control group， the difference was statistically significant （P<0.05）. After treatment， the total effective rate of the combined group was 92.11%， which was significantly higher than 71.05% of the control group， the difference was statistically significant （P<0.05）. Conclusion： Ceftazidime combined with Levofloxacin has a good effect in the treatment of elderly HF complicated with pulmonary infection， which can not only effectively remove the pathogenic bacteria， reduce serum WBC and PCT levels， but also improve patients’ pulmonary infection and heart function.

[Key words] Ceftazidime Levofloxacin Heart failure Pulmonary infection WBC PCT

First-author’s address： Jiamusi Hospital of Traditional Chinese Medicine， Jiamusi 154002， China

doi：10.3969/j.issn.1674-4985.2021.16.010

心力衰竭（heart failure， HF）是多發于老年人的一种疾病，是心血管疾病的最终走向[1]。并且HF后往往会出现肺部感染的情况，肺部感染又极易诱发HF，两者相互影响，导致患者病情加重，治疗难度加大，甚至威胁患者生命[2]。临床上治疗感染的药品主要为头孢菌素类、喹诺酮类和青霉素三大类[3]。HF合并肺部感染属于急性病症，只使用其中一种药物见效缓慢，采用加量的方法可能会使病原菌产生抗药性。……