微生态疗法在轮状病毒腹泻患儿中的疗效及对胃肠激素的影响观察

袁玉

【摘要】 目的：观察与研究微生态疗法在轮状病毒腹泻患儿中的疗效及对胃肠激素的影响。方法：选取2019年1月-2020年5月100例轮状病毒腹瀉患儿，将其随机分为对照组和观察组，每组50例。对照组采用常规治疗，观察组在对照组的基础上加用微生态疗法。比较两组治疗的总有效率、腹泻相关症状体征（呕吐、腹泻及体温）改善时间及治疗前和治疗3、7 d后的腹泻相关症状体征积分及胃肠激素水平（胃泌素、胃动素、血管活性肠肽）。结果：观察组的腹泻相关症状体征改善时间均短于对照组，差异均有统计学意义（P<0.05）。治疗3、7 d后，观察组的总有效率均高于对照组，差异均有统计学意义（P<0.05）。治疗前，两组的腹泻相关症状体征积分及胃肠激素水平比较，差异均无统计学意义（P>0.05）;治疗3、7 d后，观察组的腹泻相关症状体征积分及胃肠激素水平均低于对照组，差异均有统计学意义（P<0.05）。结论：微生态疗法在轮状病毒腹泻患儿中的疗效较好，且对胃肠激素具有积极的改善作用，具有较高的应用价值。

【关键词】 微生态疗法 轮状病毒腹泻 胃肠激素

Observation on the Effect of Microecological Therapy in the Children with Rotavirus Diarrhea and Influence for Gastrointestinal Hormones/YUAN Yu. //Medical Innovation of China， 2021， 18（16）： 0-053

[Abstract] Objective： To observe and study the effect of microecological therapy in the children with rotavirus diarrhea and influence for gastrointestinal hormones. Method： A total of 100 children with rotavirus diarrhea from January 2019 to May 2020 were selected， and they were randomly divided into control group and observation group， 50 cases in each group. The control group was treated with conventional treatment， and the observation group was treated with microecological therapy on the basis of control group. The total effective rate， improvement time of diarrhea related symptoms and signs （vomiting， diarrhea and body temperature） were compared between two groups， scores of diarrhea related symptoms and signs and gastrointestinal hormones （gastrin， motilin， vasoactive intestinal peptide） levels before treatment and 3， 7 days after treatment were compared between two groups. Result： The improvement time of diarrhea related symptoms and signs of observation group were shorter than those of control group， with statistical significance （P<0.05）. After 3 and 7 days of treatment， the total effective rates of observation group were higher than those of the control group， with statistical significance （P<0.05）. Before treatment， there were no significance differences in the scores of diarrhea related symptoms and signs and the levels of gastrointestinal hormones between two groups （P>0.05）; after 3 and 7 days of treatment， the scores of diarrhea related symptoms and signs and the levels of gastrointestinal hormones of observation group were lower than those of control group， with statistical significance （P<0.05）. Conclusion： Microecological therapy has a good effect in children with rotavirus diarrhea and has a positive effect on the improvement of gastrointestinal hormones， it has a high application value.

[Key words] Microecological therapy Rotavirus diarrhea Gastrointestinal hormones

First-author’s address： Jiamusi Maternal and Child Health Hospital， Jiamusi 154000， China

doi：10.3969/j.issn.1674-4985.2021.16.012

轮状病毒腹泻在儿童中发病率较高，可导致患儿出现腹痛、腹泻等一系列症状体征，影响患儿的机体状态，易引起电解质紊乱及脱水等情况[1-2]。临床中与轮状病毒腹泻相关的诊治研究中，除症状体征治疗研究外，机体多方面的变化也是研究重点，其中胃肠激素是在本类患儿中表现相对突出且改善需求相对较高的方面。近年来采用微生态疗法用于本类患儿治疗的研究不断增多，效果广受肯定，但深入的研究却不足[3-5]。……